Reactome | Heparin binds PKR

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Heparin binds PKR Show undefined attributes

authored	[InstanceEdit:9835112] Stephan, Ralf, 2023-05-11
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9835124] Stephan, Ralf, 2023-05-11
dbId	9835121
displayName	Heparin binds PKR
edited	[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
eventOf	[Pathway:R-HSA-9833482] PKR-mediated signaling - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-168699] EIF2AK2 [cytosol] [ChemicalDrug:R-ALL-9835132] heparin [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9835117] Heparin activates PKR by inducing dimerization [LiteratureReference:9835127] Identification of the heparin-binding domains of the interferon-induced protein kinase, PKR [LiteratureReference:9835122] Characterization of the heparin-mediated activation of PKR, the interferon-inducible RNA-dependent protein kinase [LiteratureReference:9835123] Contribution of double-stranded RNA-activated protein kinase toward antiproliferative actions of heparin on vascular smooth muscle cells
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Heparin binds PKR
orthologousEvent	[Reaction:R-PFA-9835121] Heparin binds PKR - Plasmodium falciparum [Reaction:R-DDI-9835121] Heparin binds PKR - Dictyostelium discoideum [Reaction:R-CEL-9835121] Heparin binds PKR - Caenorhabditis elegans [Reaction:R-DME-9835121] Heparin binds PKR - Drosophila melanogaster [Reaction:R-GGA-9835121] Heparin binds PKR - Gallus gallus [Reaction:R-XTR-9835121] Heparin binds PKR - Xenopus tropicalis [Reaction:R-DRE-9835121] Heparin binds PKR - Danio rerio [Reaction:R-SSC-9835121] Heparin binds PKR - Sus scrofa [Reaction:R-BTA-9835121] Heparin binds PKR - Bos taurus [Reaction:R-CFA-9835121] Heparin binds PKR - Canis familiaris [Reaction:R-RNO-9835121] Heparin binds PKR - Rattus norvegicus [Reaction:R-MMU-9835121] Heparin binds PKR - Mus musculus
output	[Complex:R-HSA-9835118] EIF2AK2 dimer:heparin [cytosol]
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9835121
summation	[Summation:9835129] Heparin is a mixture of glycosaminoglycan polymers of differ...

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(hasEvent)

[Pathway:R-HSA-9833482] PKR-mediated signaling