Reactome | MITF-M-dependent MLANA gene expression

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MITF-M-dependent MLANA gene expression Show undefined attributes

authored	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:5668575] melanosome membrane
created	[InstanceEdit:9825866] Rothfels, Karen, 2023-01-27
dbId	9825856
displayName	MITF-M-dependent MLANA gene expression
edited	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
eventOf	[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9825826] MLANA gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9855987] MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes [LiteratureReference:9855999] The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation [LiteratureReference:9855989] MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma [LiteratureReference:9854815] Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma [LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes [LiteratureReference:9730403] MITF-the first 25 years
maxDepth	1
modified	[InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M-dependent MLANA gene expression
output	[EntityWithAccessionedSequence:R-HSA-9825829] MLANA [melanosome membrane]
precedingEvent	[Reaction:R-HSA-9825844] MITF-M dimer binds MLANA gene - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9825864] Positive gene expression regulation by 'MITF-M dimer:MLANA gene [nucleoplasm]'
regulationReference	[RegulationReference:9825839] Positive gene expression regulation by 'MITF-M dimer:MLANA gene [nucleoplasm]' MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9825856
summation	[Summation:9856031] MLANA plays a role in melanosome maturation by interacting w...

Referrals

(hasEvent)

[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation