Reactome | SIRT1 deacetylates HINT1 dimer

Schema > Reaction > Entries

SIRT1 deacetylates HINT1 dimer Show undefined attributes

authored	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
catalystActivity	[CatalystActivity:9626963] protein lysine deacetylase activity of SIRT1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9825771] Rothfels, Karen, 2023-01-26
dbId	9825772
displayName	SIRT1 deacetylates HINT1 dimer
edited	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
eventOf	[Pathway:R-HSA-9856649] Transcriptional and post-translational regulation of MITF-M expression and activity - Homo sapiens
followingEvent	[Reaction:R-HSA-9825747] CREBBP acetylates HINT1 dimer - Homo sapiens [Reaction:R-HSA-9825751] HINT1 binds MITF-M - Homo sapiens
input	[Complex:R-HSA-9825712] Ac-K21, K30 HINT1 dimer [nucleoplasm] 4 × [SimpleEntity:R-ALL-113518] H2O [nucleoplasm] 4 × [SimpleEntity:R-ALL-427523] NAD+ [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9825507] Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells [LiteratureReference:9825529] The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells [LiteratureReference:2581435] Lysine acetylation targets protein complexes and co-regulates major cellular functions [LiteratureReference:9854874] Post-translational modification of HINT1 mediates activation of MITF transcriptional activity in human melanoma cells [LiteratureReference:9825667] Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for ?-catenin or MITF in colon cancer and melanoma cells [LiteratureReference:9825671] The tumor suppressor HINT1 regulates MITF and ?-catenin transcriptional activity in melanoma cells
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SIRT1 deacetylates HINT1 dimer
orthologousEvent	[Reaction:R-DDI-9825772] SIRT1 deacetylates HINT1 dimer - Dictyostelium discoideum [Reaction:R-DRE-9825772] SIRT1 deacetylates HINT1 dimer - Danio rerio [Reaction:R-CEL-9825772] SIRT1 deacetylates HINT1 dimer - Caenorhabditis elegans [Reaction:R-DME-9825772] SIRT1 deacetylates HINT1 dimer - Drosophila melanogaster [Reaction:R-GGA-9825772] SIRT1 deacetylates HINT1 dimer - Gallus gallus [Reaction:R-SSC-9825772] SIRT1 deacetylates HINT1 dimer - Sus scrofa [Reaction:R-BTA-9825772] SIRT1 deacetylates HINT1 dimer - Bos taurus [Reaction:R-CFA-9825772] SIRT1 deacetylates HINT1 dimer - Canis familiaris [Reaction:R-RNO-9825772] SIRT1 deacetylates HINT1 dimer - Rattus norvegicus [Reaction:R-MMU-9825772] SIRT1 deacetylates HINT1 dimer - Mus musculus
output	4 × [SimpleEntity:R-ALL-427498] 2'-O-acetyl-ADP-ribose [nucleoplasm] [Complex:R-HSA-9825721] HINT1 dimer [nucleoplasm] 4 × [SimpleEntity:R-ALL-427497] NAM [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9825747] CREBBP acetylates HINT1 dimer - Homo sapiens [BlackBoxEvent:R-HSA-9854916] MITF-M-dependent SIRT1 gene expression - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9825772
summation	[Summation:9854888] HINT1 is a transcriptional repressor protein with tumor supp...

Referrals

(hasEvent)	[Pathway:R-HSA-9856649] Transcriptional and post-translational regulation of MITF-M expression and activity
(precedingEvent)	[Reaction:R-HSA-9825751] HINT1 binds MITF-M [Reaction:R-HSA-9825747] CREBBP acetylates HINT1 dimer

Cite Us!