Reactome | FXa mimetic binds SERPINC1:SERPINC1 activators

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FXa mimetic binds SERPINC1:SERPINC1 activators Show undefined attributes

authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9823495] Shamovsky, Veronica, 2023-01-06
crossReference	[DatabaseIdentifier:12020767] Mondo:0001531
dbId	9823498
disease	[Disease:9696604] blood coagulation disease
displayName	FXa mimetic binds SERPINC1:SERPINC1 activators
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
eventOf	[Pathway:R-HSA-9769739] Regulation of clotting cascade - Homo sapiens
input	[ProteinDrug:R-ALL-9823325] andexanet alfa [extracellular region] [Complex:R-HSA-140799] SERPINC1:SERPINC1 activators [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9823299] A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa [LiteratureReference:9823293] Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors
maxDepth	1
modified	[InstanceEdit:9980342] Shamovsky, Veronica, 2026-01-27
name	FXa mimetic binds SERPINC1:SERPINC1 activators FXa mimetic+ SERPINC1:SERPINC1 activators-> FXa:SERPINC1:SERPINC1 activators
output	[Complex:R-HSA-9823496] andexanet alfa:SERPINC1:SERPINC1 activators [plasma membrane]
precedingEvent	[Reaction:R-HSA-140806] SERPINC1 binds SERPINC1 activators - Homo sapiens
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9823498
summation	[Summation:9823502] Andexanet alfa (PRT4445, marketed as Andexxa�) is a recombin...

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[Pathway:R-HSA-9769739] Regulation of clotting cascade

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