Reactome | CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum

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CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum Show undefined attributes

authored	[InstanceEdit:9816274] Orlic-Milacic, Marija, 2022-09-02
catalystActivity	[CatalystActivity:9932289] dolichyl-diphosphooligosaccharide-protein glycotransferase activity of OST-A [endoplasmic reticulum membrane]
category	uncertain
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:5263265] lumenal side of endoplasmic reticulum membrane
created	[InstanceEdit:9816274] Orlic-Milacic, Marija, 2022-09-02
dbId	9816276
displayName	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
eventOf	[Pathway:R-HSA-9768727] Regulation of CDH1 posttranslational processing and trafficking to plasma membrane - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9816273] CDH1 translocates from ER to Golgi - Homo sapiens [BlackBoxEvent:R-HSA-9932344] MOGS removes terminal glucose from Glu3Man9GlcNAc2-CDH1 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-449651] (Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-9932157] CDH1(23-882) [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9816239] Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD [LiteratureReference:9816262] N-glycosylation affects the adhesive function of E-Cadherin through modifying the composition of adherens junctions (AJs) in human breast carcinoma cell line MDA-MB-435 [LiteratureReference:9816218] The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila [LiteratureReference:9816269] N-glycosylation affects the molecular organization and stability of E-cadherin junctions
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum
orthologousEvent	[BlackBoxEvent:R-GGA-9816276] CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum - Gallus gallus [BlackBoxEvent:R-XTR-9816276] CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum - Xenopus tropicalis [BlackBoxEvent:R-DRE-9816276] CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum - Danio rerio [BlackBoxEvent:R-SSC-9816276] CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum - Sus scrofa [BlackBoxEvent:R-BTA-9816276] CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum - Bos taurus [BlackBoxEvent:R-CFA-9816276] CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum - Canis familiaris [BlackBoxEvent:R-RNO-9816276] CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum - Rattus norvegicus [BlackBoxEvent:R-MMU-9816276] CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum - Mus musculus
output	4 × [SimpleEntity:R-ALL-449311] DOLP [lumenal side of endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-9932178] Glu3Man9GlcNAc2-CDH1(23-882) [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9932162] Removal of CDH1 signal peptide - Homo sapiens
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9816276
summation	[Summation:9932335] CDH1 (E-cadherin) is N-glycosylated at asparagine residue...
updateTrackers	[UpdateTracker:9984562] Update Tracker - [BlackBoxEvent:9816276] CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984562] Update Tracker - [BlackBoxEvent:9816276] CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum - v96:[modifyText]
(precedingEvent)	[BlackBoxEvent:R-HSA-9816273] CDH1 translocates from ER to Golgi [BlackBoxEvent:R-HSA-9932344] MOGS removes terminal glucose from Glu3Man9GlcNAc2-CDH1
(hasEvent)	[Pathway:R-HSA-9768727] Regulation of CDH1 posttranslational processing and trafficking to plasma membrane

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