Reactome | TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane]

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TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:9818825] ubiquitin-protein transferase activity of TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-HSA-9796346] MIB2 ubiquitinates RIPK1 at K377, K604, K634 - Homo sapiens
created	[InstanceEdit:9796337] Shamovsky, Veronica, 2022-08-09
dbId	9796354
displayName	TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-1472879] MIB2 [cytosol] [Complex:R-HSA-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] [Complex:R-HSA-8939319] Ub:UBE2D1 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] - Mus musculus [Complex:R-RNO-9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] - Canis familiaris [Complex:R-BTA-9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] - Bos taurus [Complex:R-SSC-9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] - Sus scrofa [Complex:R-DRE-9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] - Danio rerio [Complex:R-XTR-9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] - Gallus gallus
isChimeric	false
literatureReference	[LiteratureReference:9796358] Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential
maxDepth	6
name	TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1
producedByEvent	[Reaction:R-HSA-9796342] MIB2 binds RIPK1 within TNF-?:TNFR1:TRADD:RIPK1:TRAF2 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9796354
updateTrackers	[UpdateTracker:9928552] Update Tracker - [Complex:9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] - v91:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9928552] Update Tracker - [Complex:9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] - v91:[updateContainedComponent]
(input)	[BlackBoxEvent:R-HSA-9796346] MIB2 ubiquitinates RIPK1 at K377, K604, K634
(physicalEntity)	[CatalystActivity:9818825] ubiquitin-protein transferase activity of TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane]
(output)	[Reaction:R-HSA-9796342] MIB2 binds RIPK1 within TNF-?:TNFR1:TRADD:RIPK1:TRAF2

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