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Schema
>
BlackBoxEvent
>
Entries
PRKN polyubiquitinates RIPK3
Show undefined attributes
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authored
[InstanceEdit:9793470] Shamovsky, Veronica, 2022-06-15
catalystActivity
[CatalystActivity:9794187] ubiquitin-protein transferase activity of RIPK3:p-S9-PRKN:Ub:UBE2L3 [cytosol]
catalystActivityReference
[CatalystActivityReference:9794188] ubiquitin-protein transferase activity of RIPK3:p-S9-PRKN:Ub:UBE2L3 [cytosol] The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
category
omitted
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9793470] Shamovsky, Veronica, 2022-06-15
dbId
9793485
displayName
PRKN polyubiquitinates RIPK3
edited
[InstanceEdit:9819392] Shamovsky, Veronica, 2022-11-04
eventOf
[Pathway:R-HSA-5675482] Regulation of necroptotic cell death - Homo sapiens
input
[Complex:R-HSA-9793473] RIPK3:p-S9-PRKN:Ub:UBE2L3 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9793492] The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
maxDepth
1
modified
[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
name
PRKN polyubiquitinates RIPK3
orthologousEvent
[BlackBoxEvent:R-BTA-9793485] PRKN polyubiquitinates RIPK3 - Bos taurus
[BlackBoxEvent:R-CFA-9793485] PRKN polyubiquitinates RIPK3 - Canis familiaris
[BlackBoxEvent:R-RNO-9793485] PRKN polyubiquitinates RIPK3 - Rattus norvegicus
[BlackBoxEvent:R-MMU-9793485] PRKN polyubiquitinates RIPK3 - Mus musculus
output
[EntityWithAccessionedSequence:R-HSA-9794180] K33polyUb-K197,302,364-RIPK3 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9793481] p-S9-PRKN [cytosol]
[EntityWithAccessionedSequence:R-HSA-8864201] Ub-C86-UBE2L3 [cytosol]
precedingEvent
[Reaction:R-HSA-9793472] RIPK3 binds p-S9-PRKN - Homo sapiens
releaseDate
2022-12-07
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9820382] Murphy, James M, 2022-11-07
[InstanceEdit:9794397] D'Eustachio, Peter, 2022-07-05
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9793485
summation
[Summation:9794179] E3 ubiquitin-protein ligase parkin (PRKN, also known as PARK...
Referrals
(hasEvent)
[Pathway:R-HSA-5675482] Regulation of necroptotic cell death
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