Reactome | Formation of the CSTF complex

Schema > Reaction > Entries

Formation of the CSTF complex Show undefined attributes

authored	[InstanceEdit:9770563] Ahluwalia, Rhea, 2025-10-01
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9770561] Orlic-Milacic, Marija, 2022-04-06
dbId	9770559
displayName	Formation of the CSTF complex
edited	[InstanceEdit:9971425] Orlic-Milacic, Marija, 2025-11-06
eventOf	[Pathway:R-HSA-9770562] mRNA Polyadenylation - Homo sapiens
followingEvent	[Reaction:R-HSA-9770123] Formation of the core cleavage and polyadenylation complex - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-72001] CSTF1 [nucleoplasm] 2 × [DefinedSet:R-HSA-8938794] CSTF2,CSTF2T [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-72005] CSTF3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8938804] Complex protein interactions within the human polyadenylation machinery identify a novel component [LiteratureReference:9969973] The hinge domain of the cleavage stimulation factor protein CstF-64 is essential for CstF-77 interaction, nuclear localization, and polyadenylation [LiteratureReference:9770922] Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylation [LiteratureReference:8938785] Overlapping and distinct functions of CstF64 and CstF64? in mammalian mRNA 3' processing [LiteratureReference:9970092] The structural basis of CstF-77 modulation of cleavage and polyadenylation through stimulation of CstF-64 activity [LiteratureReference:9970099] A missense mutation in the CSTF2 gene that impairs the function of the RNA recognition motif and causes defects in 3' end processing is associated with intellectual disability in humans [LiteratureReference:9970105] Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3'-end processing signals
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Formation of the CSTF complex
orthologousEvent	[Reaction:R-PFA-9770559] Formation of the CSTF complex - Plasmodium falciparum [Reaction:R-DDI-9770559] Formation of the CSTF complex - Dictyostelium discoideum [Reaction:R-CEL-9770559] Formation of the CSTF complex - Caenorhabditis elegans [Reaction:R-DME-9770559] Formation of the CSTF complex - Drosophila melanogaster [Reaction:R-GGA-9770559] Formation of the CSTF complex - Gallus gallus [Reaction:R-DRE-9770559] Formation of the CSTF complex - Danio rerio [Reaction:R-SSC-9770559] Formation of the CSTF complex - Sus scrofa [Reaction:R-BTA-9770559] Formation of the CSTF complex - Bos taurus [Reaction:R-CFA-9770559] Formation of the CSTF complex - Canis familiaris [Reaction:R-RNO-9770559] Formation of the CSTF complex - Rattus norvegicus [Reaction:R-MMU-9770559] Formation of the CSTF complex - Mus musculus
output	[Complex:R-HSA-9970107] CSTF hexamer [nucleoplasm]
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9971220] Ahluwalia, Rhea, 2025-11-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9770559
summation	[Summation:9969442] The CSTF (cleavage stimulation factor) complex, which det...

Referrals

(hasEvent)	[Pathway:R-HSA-9770562] mRNA Polyadenylation
(precedingEvent)	[Reaction:R-HSA-9770123] Formation of the core cleavage and polyadenylation complex

Cite Us!