Reactome | GspD2:GspC2:GspS2 transports LT from periplasmic to extracellular space

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GspD2:GspC2:GspS2 transports LT from periplasmic to extracellular space Show undefined attributes

authored	[InstanceEdit:9760662] Stephan, Ralf, 2021-12-21
catalystActivity	[CatalystActivity:9760693] protein transmembrane transporter activity of GspD2:GspC2:GspS2 [periplasmic space]
category	transition
compartment	[Compartment:1222638] periplasmic space [Compartment:20798] cell outer membrane [Compartment:984] extracellular region
created	[InstanceEdit:9760696] Stephan, Ralf, 2021-12-22
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9760705
disease	[Disease:3134792] bacterial infectious disease
displayName	GspD2:GspC2:GspS2 transports LT from periplasmic to extracellular space
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9760173] Secretion of toxins - Homo sapiens
input	[Complex:R-ECO-9760660] LT [periplasmic space]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9760687] YghG (GspS?) is a novel pilot protein required for localization of the GspS? type II secretion system secretin of enterotoxigenic Escherichia coli [LiteratureReference:9760691] Identification of a protein secretory pathway for the secretion of heat-labile enterotoxin by an enterotoxigenic strain of Escherichia coli [LiteratureReference:9760698] The binding of cholera toxin to the periplasmic vestibule of the type II secretion channel [LiteratureReference:9760717] Type II secretion system: a magic beanstalk or a protein escalator [LiteratureReference:9760176] Specificity of the type II secretion systems of enterotoxigenic Escherichia coli and Vibrio cholerae for heat-labile enterotoxin and cholera toxin [LiteratureReference:9760694] Bacterial surface association of heat-labile enterotoxin through lipopolysaccharide after secretion via the general secretory pathway [LiteratureReference:9760830] Electron Acceptors Induce Secretion of Enterotoxigenic Escherichia coli Heat-Labile Enterotoxin under Anaerobic Conditions through Promotion of GspD Assembly [LiteratureReference:9760831] Structural insight into the assembly of the type II secretion system pilotin-secretin complex from enterotoxigenic Escherichia coli
maxDepth	1
modified	[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	GspD2:GspC2:GspS2 transports LT from periplasmic to extracellular space
output	[Complex:R-ECO-9760706] LT [extracellular region]
precedingEvent	[Reaction:R-HSA-9760663] EltA binds EltB - Homo sapiens
relatedSpecies	[Species:9760713] Escherichia coli O78:H11
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9760705
summation	[Summation:9760832] E. coli heat-labile enterotoxin (LT) is secreted from the pe...

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[Pathway:R-HSA-9760173] Secretion of toxins

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