Reactome | p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1

Schema > Reaction > Entries

p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 Show undefined attributes

authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9759167] Rothfels, Karen, 2021-11-29
dbId	9759169
displayName	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
eventOf	[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-9759172] KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer - Homo sapiens
input	[Complex:R-HSA-8932333] KEAP1:NEDD8-CUL3:RBX1 [cytosol] [Complex:R-HSA-9766527] p-S349 SQSTM1 oligomer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9759063] p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription [LiteratureReference:9766496] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9758982] Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination [LiteratureReference:9759000] Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway [LiteratureReference:9759058] p62 links autophagy and Nrf2 signaling [LiteratureReference:9766515] Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage [LiteratureReference:9766507] Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1
negativePrecedingEvent	[NegativePrecedingEvent:9767158] Futile Cycle: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
orthologousEvent	[Reaction:R-DME-9759169] p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 - Drosophila melanogaster [Reaction:R-DRE-9759169] p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 - Danio rerio [Reaction:R-BTA-9759169] p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 - Bos taurus [Reaction:R-RNO-9759169] p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 - Rattus norvegicus [Reaction:R-MMU-9759169] p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 - Mus musculus
output	[Complex:R-HSA-9759099] p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
precedingEvent	[Reaction:R-HSA-9766532] SQSTM1 oligomer is phosphorylated - Homo sapiens
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9759169
summation	[Summation:9759168] SQSTM1 binds to the KEAP1 subunit of the CRL3 ubiquitin liga...

Referrals

(hasEvent)	[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway
(precedingEvent)	[Reaction:R-HSA-9759172] KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer