Reactome | IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation

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IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
catalystActivity	[CatalystActivity:975181] protein kinase activity of TRAF6:hp-IRAK1:Pellino [endosome membrane]
category	transition
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975139
displayName	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
edited	[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation - Homo sapiens
followingEvent	[Reaction:R-HSA-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-975143] TRAF6:hp-IRAK1:Pellino [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450692] The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1 [LiteratureReference:450812] Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4 [LiteratureReference:450816] Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
orthologousEvent	[Reaction:R-DME-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Drosophila melanogaster [Reaction:R-DRE-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Danio rerio [Reaction:R-SSC-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Sus scrofa [Reaction:R-BTA-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Bos taurus [Reaction:R-CFA-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Canis familiaris [Reaction:R-RNO-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Rattus norvegicus [Reaction:R-MMU-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-975166] p-Pellino:hp-IRAK1:TRAF6 [endosome membrane]
precedingEvent	[Reaction:R-HSA-975142] Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975139
summation	[Summation:940396] Both IRAK1 and IRAK4 were shown to phosphorylate Pellino iso...
updateTrackers	[UpdateTracker:9788476] Update Tracker - [Reaction:975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - v42:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788476] Update Tracker - [Reaction:975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - v42:[modifyText]
(hasEvent)	[Pathway:R-HSA-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
(precedingEvent)	[Reaction:R-HSA-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation