Reactome | MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3

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MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 Show undefined attributes

authored	[InstanceEdit:9731110] Orlic-Milacic, Marija, 2021-05-13
catalystActivity	[CatalystActivity:4793923] protein serine/threonine kinase activity of p-T,Y MAPK dimers [cytosol]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9731110] Orlic-Milacic, Marija, 2021-05-13
dbId	9731111
displayName	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3
edited	[InstanceEdit:9773649] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-171172] SMAD2,3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9731118] A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras [LiteratureReference:9731123] Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3 [LiteratureReference:9731136] Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation [LiteratureReference:9731142] The role of specific Smad linker region phosphorylation in TGF-? mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3
negativePrecedingEvent	[NegativePrecedingEvent:9754410] Futile Cycle: Dephosphorylated SMAD2/3 translocates to the cytosol
orthologousEvent	[Reaction:R-CEL-9731111] MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 - Caenorhabditis elegans [Reaction:R-DME-9731111] MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 - Drosophila melanogaster [Reaction:R-GGA-9731111] MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 - Gallus gallus [Reaction:R-XTR-9731111] MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 - Xenopus tropicalis [Reaction:R-DRE-9731111] MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 - Danio rerio [Reaction:R-SSC-9731111] MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 - Sus scrofa [Reaction:R-BTA-9731111] MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 - Bos taurus [Reaction:R-CFA-9731111] MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 - Canis familiaris [Reaction:R-RNO-9731111] MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 - Rattus norvegicus [Reaction:R-MMU-9731111] MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-9731119] p-S250-SMAD2,p-S208-SMAD3 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9732753] JAK1-activated RAF1 phosphorylates MAPKs - Homo sapiens
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9731111
summation	[Summation:9731131] MAPK1 (ERK2) and MAPK3 (ERK1) phosphorylate SMAD2 and SMAD3 ...

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(hasEvent)

[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity