Reactome | SLC5A2 binds gliflozins

Schema > Reaction > Entries

SLC5A2 binds gliflozins Show undefined attributes

authored	[InstanceEdit:9728224] Jassal, Bijay, 2021-04-20
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9728224] Jassal, Bijay, 2021-04-20
dbId	9728150
definition	Inhibition
displayName	SLC5A2 binds gliflozins
edited	[InstanceEdit:9728224] Jassal, Bijay, 2021-04-20 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-189200] Cellular hexose transport - Homo sapiens
input	[DefinedSet:R-ALL-9728134] gliflozins [extracellular region] [EntityWithAccessionedSequence:R-HSA-429568] SLC5A2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9728535] Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level [LiteratureReference:9728553] Structural selectivity of human SGLT inhibitors [LiteratureReference:9728561] Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SLC5A2 binds gliflozins
orthologousEvent	[Reaction:R-GGA-9728150] SLC5A2 binds gliflozins - Gallus gallus [Reaction:R-XTR-9728150] SLC5A2 binds gliflozins - Xenopus tropicalis [Reaction:R-DRE-9728150] SLC5A2 binds gliflozins - Danio rerio [Reaction:R-SSC-9728150] SLC5A2 binds gliflozins - Sus scrofa [Reaction:R-BTA-9728150] SLC5A2 binds gliflozins - Bos taurus [Reaction:R-CFA-9728150] SLC5A2 binds gliflozins - Canis familiaris [Reaction:R-RNO-9728150] SLC5A2 binds gliflozins - Rattus norvegicus [Reaction:R-MMU-9728150] SLC5A2 binds gliflozins - Mus musculus
output	[Complex:R-HSA-9728163] SLC5A2:gliflozins [plasma membrane]
reactionType	[DrugActionType:9725066] Inhibitor
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9728150
summation	[Summation:9728530] The human gene SLC5A2 encodes sodium/glucose cotransporter 2...

Referrals

(hasEvent)

[Pathway:R-HSA-189200] Cellular hexose transport