Reactome | Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis

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Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis Show undefined attributes

authored	[InstanceEdit:9839035] Orlic-Milacic, Marija, 2023-06-29
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9727356] Orlic-Milacic, Marija, 2021-04-16
dbId	9727355
displayName	Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis
edited	[InstanceEdit:9863489] Orlic-Milacic, Marija, 2024-02-29
eventOf	[CellLineagePath:R-HSA-9725554] Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:528093] keratinocyte development
input	[Cell:R-HSA-9727357] keratinocyte of granulosum layer of epidermis
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9727376] Epidermal differentiation: the bare essentials [LiteratureReference:9727371] Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis [LiteratureReference:9727995] Interaction of the profilaggrin N-terminal domain with loricrin in human cultured keratinocytes and epidermis [LiteratureReference:9727973] "Activated" keratinocyte phenotype is unifying feature in conditions which predispose to squamous cell carcinoma of the skin [LiteratureReference:9728005] Expression of loricrin in skin disorders [LiteratureReference:9728001] Normal human epidermal keratinocytes express in vitro specific molecular forms of (pro)filaggrin recognized by rheumatoid arthritis-associated antifilaggrin autoantibodies [LiteratureReference:8934808] Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes [LiteratureReference:9727983] Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyond [LiteratureReference:9727651] Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function [LiteratureReference:9728003] Molecular basis of the skin barrier structures revealed by electron microscopy [LiteratureReference:9727984] Loricrin and human skin diseases: molecular basis of loricrin keratodermas [LiteratureReference:9727990] Immunoelectron microscopic analysis of cornified cell envelope formation in normal and psoriatic epidermis [LiteratureReference:9727663] Expression of loricrin is negatively controlled by retinoic acid in human epidermis reconstructed in vitro [LiteratureReference:9727993] Biosynthetic pathways of filaggrin and loricrin--two major proteins expressed by terminally differentiated epidermal keratinocytes [LiteratureReference:9728015] Regulation of involucrin in psoriatic epidermal keratinocytes: the roles of ERK1/2 and GSK-3? [LiteratureReference:9728040] The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation [LiteratureReference:9728042] MON-150, a versatile monoclonal antibody against involucrin: characterization and applications [LiteratureReference:9728060] Abnormal maturation pathway of keratinocytes in psoriatic skin [LiteratureReference:9728033] Characterization and expression analysis of the Spink5 gene, the mouse ortholog of the defective gene in Netherton syndrome [LiteratureReference:9728027] LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome [LiteratureReference:9728045] LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum [URL:9839244] https://doi.org/10.3180/r-hsa-6805567.1 [LiteratureReference:9728059] Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation [LiteratureReference:9728032] Homeodomain-only protein HOP is a novel modulator of late differentiation in keratinocytes [LiteratureReference:9728021] Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation [LiteratureReference:9732199] A histological and immunohistochemical study on chronic irritant contact dermatitis [LiteratureReference:9824053] The small proline-rich proteins constitute a multigene family of differentially regulated cornified cell envelope precursor proteins [LiteratureReference:9824051] AP-1 and ets transcription factors regulate the expression of the human SPRR1A keratinocyte terminal differentiation marker [LiteratureReference:9824058] Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation [LiteratureReference:9728072] Knockdown of filaggrin in a three-dimensional reconstructed human epidermis impairs keratinocyte differentiation [LiteratureReference:9728076] Evidence that filaggrin is a component of cornified cell envelopes in human plantar epidermis [LiteratureReference:9728075] Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum [LiteratureReference:9728070] Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7 [LiteratureReference:9728100] Stratum corneum-derived caspase-14 is catalytically active [LiteratureReference:9728096] Ultrastructural localization of caspase-14 in human epidermis [LiteratureReference:9839550] Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1 [LiteratureReference:9839552] Dermokine-? impairs ERK signaling through direct binding to GRP78 [LiteratureReference:9839569] Mice deficient for the epidermal dermokine ? and ? isoforms display transient cornification defects [LiteratureReference:9839573] Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression [LiteratureReference:9839579] Decreased expression of suprabasin induces aberrant differentiation and apoptosis of epidermal keratinocytes: Possible role for atopic dermatitis [LiteratureReference:9839566] Characterization of Kdap, a protein secreted by keratinocytes [LiteratureReference:9839484] PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data [LiteratureReference:9820674] CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data [LiteratureReference:9839610] Markers for Ca⁺⁺ -induced terminal differentiation of keratinocytes in vitro under defined conditions [LiteratureReference:9839613] Keratinocyte Proline-Rich Protein Deficiency�in�Atopic Dermatitis Leads to Barrier Disruption [LiteratureReference:9839618] Molecular cloning and expression of human keratinocyte proline-rich protein (hKPRP), an epidermal marker isolated from calcium-induced differentiating keratinocytes
maxDepth	1
modified	[InstanceEdit:9910918] Orlic-Milacic, Marija, 2024-05-23
name	Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis
output	[Cell:R-HSA-9855603] corneocyte
precedingEvent	[CellDevelopmentStep:R-HSA-9727359] Keratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveRegulation:R-HSA-158643] Positive regulation by 'Ca2+ [extracellular region]'
regulationReference	[RegulationReference:9839205] Positive regulation by 'Ca2+ [extracellular region]' Epidermal differentiation: the bare essentials
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861092] Ganier, Clarisse, 2024-02-13 [InstanceEdit:9907436] Matthews, Lisa, 2024-04-10
schemaClass	CellDevelopmentStep
species	[Species:48887] Homo sapiens
stId	R-HSA-9727355
summation	[Summation:9839200] During differentiation of stratum granulosum keratinocytes i...
tissue	[Anatomy:9725551] skin epidermis
updateTrackers	[UpdateTracker:9910949] Update Tracker - [CellDevelopmentStep:9727355] Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis - v89:[add_removeRegulator]

Referrals

(hasEvent)	[CellLineagePath:R-HSA-9725554] Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
(updatedInstance)	[UpdateTracker:9910949] Update Tracker - [CellDevelopmentStep:9727355] Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis - v89:[add_removeRegulator]

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