Reactome | PTGIR binds PTGIR agonists

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PTGIR binds PTGIR agonists Show undefined attributes

authored	[InstanceEdit:9726978] Jassal, Bijay, 2021-04-13
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9726978] Jassal, Bijay, 2021-04-13
dbId	9726949
definition	Agonist
displayName	PTGIR binds PTGIR agonists
edited	[InstanceEdit:9726978] Jassal, Bijay, 2021-04-13 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-392851] Prostacyclin signalling through prostacyclin receptor - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-391834] PTGIR [plasma membrane] [DefinedSet:R-ALL-9726945] PTGIR agonists [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9726998] Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist [LiteratureReference:9718022] The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs [LiteratureReference:9726957] 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PTGIR binds PTGIR agonists
orthologousEvent	[Reaction:R-DME-9726949] PTGIR binds PTGIR agonists - Drosophila melanogaster [Reaction:R-XTR-9726949] PTGIR binds PTGIR agonists - Xenopus tropicalis [Reaction:R-DRE-9726949] PTGIR binds PTGIR agonists - Danio rerio [Reaction:R-SSC-9726949] PTGIR binds PTGIR agonists - Sus scrofa [Reaction:R-BTA-9726949] PTGIR binds PTGIR agonists - Bos taurus [Reaction:R-CFA-9726949] PTGIR binds PTGIR agonists - Canis familiaris [Reaction:R-RNO-9726949] PTGIR binds PTGIR agonists - Rattus norvegicus [Reaction:R-MMU-9726949] PTGIR binds PTGIR agonists - Mus musculus
output	[Complex:R-HSA-9726966] PTGIR:PTGIR agonists [plasma membrane]
reactionType	[DrugActionType:9725061] Agonist
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9726949
summation	[Summation:9727109] The endogenous prostanoid prostacyclin is continuously produ...

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(hasEvent)

[Pathway:R-HSA-392851] Prostacyclin signalling through prostacyclin receptor