Reactome | L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3)

Schema > Reaction > Entries

L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) Show undefined attributes

authored	[InstanceEdit:9717176] May, Bruce, 2021-03-05
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9717219] May, Bruce, 2021-03-08
dbId	9717206
displayName	L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3)
edited	[InstanceEdit:9717176] May, Bruce, 2021-03-05
eventOf	[Pathway:R-HSA-9717207] Sensory perception of sweet, bitter, and umami (glutamate) taste - Homo sapiens
followingEvent	[Reaction:R-HSA-9717202] GNAT3 exchanges GDP for GTP in L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 - Homo sapiens
input	[DefinedSet:R-ALL-9737063] GMP,IMP [extracellular region] [DefinedSet:R-ALL-9749945] L-Glu,L-Asp [extracellular region] [Complex:R-HSA-9717218] TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:444632] Human receptors for sweet and umami taste [LiteratureReference:9718319] Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor) [LiteratureReference:9718329] Human genetic polymorphisms in T1R1 and T1R3 taste receptor subunits affect their function [LiteratureReference:9718273] Genetic and molecular basis of individual differences in human umami taste perception [LiteratureReference:9718288] Molecular mechanism for the umami taste synergism [LiteratureReference:9722111] Different functional roles of T1R subunits in the heteromeric taste receptors [LiteratureReference:9722102] L-Theanine elicits umami taste via the T1R1 + T1R3 umami taste receptor
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) L-Glu or L-Asp and 5' nucleotide bind TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13
orthologousEvent	[Reaction:R-GGA-9717206] L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) - Gallus gallus [Reaction:R-DRE-9717206] L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) - Danio rerio [Reaction:R-SSC-9717206] L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) - Sus scrofa [Reaction:R-BTA-9717206] L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) - Bos taurus [Reaction:R-CFA-9717206] L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) - Canis familiaris [Reaction:R-RNO-9717206] L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) - Rattus norvegicus [Reaction:R-MMU-9717206] L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) - Mus musculus
output	[Complex:R-HSA-9717187] L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane]
releaseDate	2021-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9749949] Jiang, Peihua, 2021-08-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9717206
summation	[Summation:9718280] L-glutamate or L-aspartate binds the umami taste receptor, T...

Referrals

(hasEvent)	[Pathway:R-HSA-9717207] Sensory perception of sweet, bitter, and umami (glutamate) taste
(precedingEvent)	[Reaction:R-HSA-9717202] GNAT3 exchanges GDP for GTP in L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13