Reactome | Anti-cancer drugs generate DNA interstrand crosslinks

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Anti-cancer drugs generate DNA interstrand crosslinks Show undefined attributes

authored	[InstanceEdit:9713846] Orlic-Milacic, Marija, 2021-02-01
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9713788] Orlic-Milacic, Marija, 2021-02-01
dbId	9713785
displayName	Anti-cancer drugs generate DNA interstrand crosslinks
edited	[InstanceEdit:9750078] Orlic-Milacic, Marija, 2021-08-09
eventOf	[Pathway:R-HSA-9750126] Drug-induced formation of DNA interstrand crosslinks - Homo sapiens
inferredFrom	[BlackBoxEvent:R-ECO-9750081] Carmustine produces interstrand crosslinks in E. coli DNA - Escherichia coli [BlackBoxEvent:R-ECO-9750080] Lomustine produces interstrand crosslinks in E. coli DNA - Escherichia coli [BlackBoxEvent:R-MMU-9750097] ThioTEPA produces interstrand crosslinks in mouse DNA - Mus musculus [BlackBoxEvent:R-MMU-9750281] Uramustine produces interstrand crosslinks in mouse DNA - Mus musculus
input	[DefinedSet:R-ALL-9713797] DNA crosslinking anti-cancer drugs [nucleoplasm] [GenomeEncodedEntity:R-HSA-5649637] dsDNA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:6786163] DNA interstrand crosslink repair and cancer [LiteratureReference:9713830] The evolving role of DNA inter-strand crosslinks in chemotherapy [LiteratureReference:9736495] Antibody-drug conjugates (ADCs) delivering pyrrolobenzodiazepine (PBD) dimers for cancer therapy [LiteratureReference:9736497] Interactions of mitomycin C with mammalian DNA detected by alkaline elution [LiteratureReference:9736458] DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate [LiteratureReference:9736429] Cytotoxicity, DNA cross-linking, and single strand breaks induced by activated cyclophosphamide and acrolein in human leukemia cells [LiteratureReference:9736494] Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay [LiteratureReference:9736462] Gene and human tumour cell line specific differencesin nitrogen mustard induced DNA alkylation and interstrand crosslinking frequencies [LiteratureReference:9736445] Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines [LiteratureReference:9736453] Comparative pharmacokinetics of DNA lesion formation and removal following treatment of L1210 cells with nitrogen mustards [LiteratureReference:9736428] Formation of DNA adducts by the anticancer drug carboplatin: different nucleotide sequence preferences in vitro and in cells [LiteratureReference:9736506] Formation and repair of DNA interstrand cross-links in relation to cytotoxicity and unscheduled DNA synthesis induced in control and mutant human cells treated with cis-diamminedichloroplatinum(II) [LiteratureReference:9736457] Sequence- and region-specificity of oxaliplatin adducts in naked and cellular DNA [LiteratureReference:9736455] Chemical, biochemical and pharmacological activity of the novel sterically hindered platinum co-ordination complex, cis-[amminedichloro(2-methylpyridine)] platinum(II) (AMD473) [LiteratureReference:9736482] DNA-binding properties of novel cis- and trans platinum-based anticancer agents in 2 human ovarian carcinoma cell lines [LiteratureReference:9736480] Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity [LiteratureReference:9736476] Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload [LiteratureReference:9736463] SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML [LiteratureReference:9616000] Balancing repair and tolerance of DNA damage caused by alkylating agents [LiteratureReference:9736554] The role of the N-(hydroxymethyl)melamines as antitumour agents: mechanism of action studies [LiteratureReference:9736559] Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas [LiteratureReference:9736560] Mechanism of action of fotemustine, a new chloroethylnitrosourea anticancer agent: evidence for the formation of two DNA-reactive intermediates contributing to cytotoxicity [LiteratureReference:9736569] Cellular resistance to chloroethylnitrosoureas, nitrogen mustard, and cis-diamminedichloroplatinum(II) in human glial-derived cell lines [LiteratureReference:9750089] In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473 [LiteratureReference:9750110] Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine [LiteratureReference:9750099] Interaction of N,N',N''-triethylenethiophosphoramide and N,N',N''-triethylenephosphoramide with cellular DNA
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Anti-cancer drugs generate DNA interstrand crosslinks
output	[GenomeEncodedEntity:R-HSA-6785117] ICL-DNA [nucleoplasm]
releaseDate	2021-09-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9749858] Kadambat Nair, Sisira, 2021-07-28
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9713785
summation	[Summation:9713833] Some of the earliest and still most widely used anti-cancer ...

Referrals

(hasEvent)	[Pathway:R-HSA-9750126] Drug-induced formation of DNA interstrand crosslinks
(inferredTo)	[BlackBoxEvent:R-MMU-9750281] Uramustine produces interstrand crosslinks in mouse DNA [BlackBoxEvent:R-MMU-9750097] ThioTEPA produces interstrand crosslinks in mouse DNA [BlackBoxEvent:R-ECO-9750081] Carmustine produces interstrand crosslinks in E. coli DNA [BlackBoxEvent:R-ECO-9750080] Lomustine produces interstrand crosslinks in E. coli DNA

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