Reactome | NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2

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NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 Show undefined attributes

authored	[InstanceEdit:9712272] Stephan, Ralf, 2021-01-15
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9712273] Stephan, Ralf, 2021-01-18
dbId	9712274
deleted	[Deleted:9768284] Deletion of instance: 8932334
displayName	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2
edited	[InstanceEdit:9712273] Stephan, Ralf, 2021-01-18
eventOf	[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway - Homo sapiens [Pathway:R-HSA-9679191] Potential therapeutics for SARS - Homo sapiens
input	[Complex:R-HSA-8932286] KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] [DefinedSet:R-ALL-9714134] NFE2L2 inducers [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9766101] Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases [LiteratureReference:8932329] Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers [LiteratureReference:8932301] Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress [LiteratureReference:9712271] Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane [LiteratureReference:9712283] Modification of keap1 cysteine residues by sulforaphane [LiteratureReference:9714136] Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1 [LiteratureReference:9714148] Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro [LiteratureReference:9731763] SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate [LiteratureReference:9731734] Sulforaphane exhibits in vitro and in vivo antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2
orthologousEvent	[Reaction:R-PFA-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Plasmodium falciparum [Reaction:R-DDI-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Dictyostelium discoideum [Reaction:R-CEL-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Caenorhabditis elegans [Reaction:R-DME-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Drosophila melanogaster [Reaction:R-GGA-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Gallus gallus [Reaction:R-XTR-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Xenopus tropicalis [Reaction:R-DRE-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Danio rerio [Reaction:R-SSC-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Sus scrofa [Reaction:R-BTA-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Bos taurus [Reaction:R-CFA-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Canis familiaris [Reaction:R-RNO-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Rattus norvegicus [Reaction:R-MMU-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Mus musculus
output	[Complex:R-HSA-9712276] NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol]
precedingEvent	[Reaction:R-HSA-8932327] NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23 [InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
revised	[InstanceEdit:9766710] Rothfels, Karen, 2022-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9712274
summation	[Summation:9712253] KEAP1:CUL3:RBX1-mediated degradation of NFE2L2 is relieved i...
updateTrackers	[UpdateTracker:9775021] Update Tracker - [Reaction:9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - v80:[addLiteratureReference, modifyText] [UpdateTracker:9776013] Update Tracker - [Reaction:9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - v78:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775021] Update Tracker - [Reaction:9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - v80:[addLiteratureReference, modifyText] [UpdateTracker:9776013] Update Tracker - [Reaction:9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - v78:[addLiteratureReference, modifyText]
(replacementInstances)	[Deleted:9768284] Deletion of instance: 8932334
(hasEvent)	[Pathway:R-HSA-9679191] Potential therapeutics for SARS [Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway

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