Reactome | FLT3 phosphorylates GRB10

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FLT3 phosphorylates GRB10 Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity	[CatalystActivity:9706342] protein tyrosine kinase activity of active FLT3:GRB10 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9706339] Rothfels, Karen, 2020-11-04
dbId	9706344
displayName	FLT3 phosphorylates GRB10
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9607240] FLT3 Signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9706340] Active FLT3:p-Y-GRB10 binds PIK3R1 - Homo sapiens
input	[Complex:R-HSA-9706260] active FLT3:GRB10 [plasma membrane] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9706098] FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	FLT3 phosphorylates GRB10
orthologousEvent	[Reaction:R-XTR-9706344] FLT3 phosphorylates GRB10 - Xenopus tropicalis [Reaction:R-SSC-9706344] FLT3 phosphorylates GRB10 - Sus scrofa [Reaction:R-BTA-9706344] FLT3 phosphorylates GRB10 - Bos taurus [Reaction:R-CFA-9706344] FLT3 phosphorylates GRB10 - Canis familiaris [Reaction:R-MMU-9706344] FLT3 phosphorylates GRB10 - Mus musculus
output	[Complex:R-HSA-9706279] active FLT3:p-Y GRB10 [plasma membrane] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-9706308] Active FLT3 binds to GRB10 - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9706344
summation	[Summation:9706343] GRB10 is phosphorylated in response to treatment of cells wi...

Referrals

(hasEvent)	[Pathway:R-HSA-9607240] FLT3 Signaling
(precedingEvent)	[Reaction:R-HSA-9706340] Active FLT3:p-Y-GRB10 binds PIK3R1

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