Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Show undefined attributes
Go to Details
authored
[InstanceEdit:9704652] Orlic-Milacic, Marija, 2020-10-09
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9704645] Orlic-Milacic, Marija, 2020-10-09
dbId
9704646
disease
[Disease:1500689] cancer
displayName
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
edited
[InstanceEdit:9724778] Orlic-Milacic, Marija, 2021-03-25
[InstanceEdit:9749764] Orlic-Milacic, Marija, 2021-08-05
eventOf
[Pathway:R-HSA-9701193] Defective homologous recombination repair (HRR) due to PALB2 loss of function - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[FailedReaction:R-HSA-9704408] Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5685831] Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair
[LiteratureReference:9704369] A recurrent mutation in PALB2 in Finnish cancer families
[LiteratureReference:9749727] Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif
modified
[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
normalPathway
[Pathway:R-HSA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
releaseDate
2021-06-09
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9724719] Winqvist, Robert, 2021-02-25
[InstanceEdit:9724724] Pospiech, Helmut, 2021-02-25
[InstanceEdit:9749768] Milano de Souza, Larissa, 2021-07-25
[InstanceEdit:9749767] Masson, Jean-Yves, 2021-07-25
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9704646
summation
[Summation:9704649] Mutations affecting the C-terminal WD40 domain of PALB2 (ami...
Referrals
(hasEvent)
[Pathway:R-HSA-9701193] Defective homologous recombination repair (HRR) due to PALB2 loss of function
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text