Reactome | FLT3 mutants bind TKIs

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FLT3 mutants bind TKIs Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9702511] Rothfels, Karen, 2020-09-30
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9702509
disease	[Disease:1500689] cancer
displayName	FLT3 mutants bind TKIs
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9682385] FLT3 signaling in disease - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9702510] FLT mutants bind type II TKIs - Homo sapiens [Reaction:R-HSA-9702508] FLT mutants bind type I TKIs - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications [LiteratureReference:9683353] Targeting FLT3 mutations in AML: review of current knowledge and evidence [LiteratureReference:9703031] The importance of FLT3 mutational analysis in acute myeloid leukemia
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 mutants bind TKIs
normalPathway	[Pathway:R-HSA-9607240] FLT3 Signaling
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9702509
summation	[Summation:9703050] Aberrant signaling by activated forms of FLT3 can be inhibit...

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[Pathway:R-HSA-9682385] FLT3 signaling in disease

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