Reactome | CFTR F508del binds CFTR correctors

Schema > Reaction > Entries

CFTR F508del binds CFTR correctors Show undefined attributes

authored	[InstanceEdit:9724665] Jassal, Bijay, 2021-03-25
category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9700279] Jassal, Bijay, 2020-09-15
crossReference	[DatabaseIdentifier:12020976] Mondo:0009061
dbId	9700266
disease	[Disease:5678942] cystic fibrosis
displayName	CFTR F508del binds CFTR correctors
edited	[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-5678895] Defective CFTR causes cystic fibrosis - Homo sapiens
input	[CandidateSet:R-ALL-9700238] CFTR correctors [cytosol] [EntityWithAccessionedSequence:R-HSA-8866834] CFTR F508del [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9700265] VX-445-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles [LiteratureReference:9700244] VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles [LiteratureReference:9700232] Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial [LiteratureReference:9700237] Correcting CFTR folding defects by small-molecule correctors to cure cystic fibrosis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CFTR F508del binds CFTR correctors
output	[Complex:R-HSA-9700270] CFTR F508del:CFTR correctors [endoplasmic reticulum membrane]
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9700266
summation	[Summation:9700236] Cystic fibrosis (CF) is caused by mutations in the cystic fi...

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(hasEvent)

[Pathway:R-HSA-5678895] Defective CFTR causes cystic fibrosis

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