Reactome | ALK fusion protein dimers [cytosol]

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ALK fusion protein dimers [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:9700109] protein tyrosine kinase activity of ALK fusion protein dimers [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane [Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-9700181] Autophosphorylation of ALK fusions - Homo sapiens
created	[InstanceEdit:9700089] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700079
disease	[Disease:1500689] cancer
displayName	ALK fusion protein dimers [cytosol]
hasCandidate	[Complex:R-HSA-9700526] WDCP(1-680)-ALK(1061-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9710896] CLTC(2-1634)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9710898] ATIC(1-229)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9710891] EEF1G(1-343)-ALK(1106-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712029] KLC1(1-420)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712019] HIP1(1-1019)-ALK(1058-1620) dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712023] HIP1(1-719)InsL-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712025] HIP1(1-963)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712016] TPR(2-629)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712021] DCTN1(1-1177)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712036] DCTN1(1-599)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712008] SQSTM1(2-251)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712033] PPFIBP1(1-232)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712027] PPFIBP1(1-349)InsK-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712009] CARS1(2-606)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713499] SEC31A(1-989)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713498] VCL(1-811)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713494] BIRC6(1-958)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713509] EIF2AK3(30-144)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713504] PPM1B(2-282)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713493] PRKAR1A(1-183)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713491] GCC2(1-1204)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713502] LMO7(1-1073)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9702008] RRBP1(1-1264)-ALK(1106-1620) fusion dimer [endoplasmic reticulum membrane] - Homo sapiens [Complex:R-HSA-9718453] RANBP2(1-867)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713496] BCL11A(1-219)InsDHPPA-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9730700] NPM1(1-117)-ALK(1068-1620) fusion dimer [cytosol] - Homo sapiens
hasMember	[Complex:R-HSA-9700022] EML4(1-486)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699985] EML4(1-223)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699976] EML4(1-223)insKMSTREKNSQV -ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9699999] NPM1(1-117)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9702017] TFG(1-138)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9702025] TFG(1-193)-ALK(1058-1620) dimer [cytosol] - Homo sapiens [Complex:R-HSA-9702034] TFG(1-240)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9710892] TPM3(2-258)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9710895] TPM4(2-221)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9710894] CLTC(2-1634)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9710897] ATIC(1-230)-ALK(1059-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712012] KIF5B(2-575)-ALK(1063-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9700523] STRN(1-137)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712032] DCTN1(1-1065)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9712017] MSN(2-448)-ALK(1064-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713500] FN1(32-1201)-ALK(1022-1620) fusion dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9716115] EML4(1-569)-ALK(1078-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9724104] EML4(1-780)-ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
inDisease	true
maxDepth	3
modified	[InstanceEdit:9863938] Matthews, Lisa, 2024-03-06
name	ALK fusion protein dimers
producedByEvent	[Reaction:R-HSA-9700179] Ligand-independent dimerization of ALK fusions - Homo sapiens
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9700079

Referrals

(input)	[Reaction:R-HSA-9700181] Autophosphorylation of ALK fusions
(output)	[Reaction:R-HSA-9700179] Ligand-independent dimerization of ALK fusions
(physicalEntity)	[CatalystActivity:9700109] protein tyrosine kinase activity of ALK fusion protein dimers [cytosol]

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