Reactome | FOXO3-dependent CDKN1B gene expression

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FOXO3-dependent CDKN1B gene expression Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9699582] Rothfels, Karen, 2020-09-14
dbId	9699575
displayName	FOXO3-dependent CDKN1B gene expression
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9607240] FLT3 Signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9618287] CDKN1B gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9618307] Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1) [LiteratureReference:9620538] Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells [LiteratureReference:9618273] AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 [LiteratureReference:9696003] Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation [LiteratureReference:9699298] FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications [LiteratureReference:9699307] FoxO transcription factors in cancer metabolism [LiteratureReference:9699282] FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27^Kip1 in acute myeloid leukemia
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FOXO3-dependent CDKN1B gene expression
output	[EntityWithAccessionedSequence:R-HSA-198622] CDKN1B [cytosol]
regulatedBy	[PositiveGeneExpressionRegulation:9699577] Positive gene expression regulation by 'FOXO3 [nucleoplasm]'
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9699575
summation	[Summation:9699400] The promoter of the CDKN1B gene, encoding CDK inhibitor p27K...

Referrals

(hasEvent)

[Pathway:R-HSA-9607240] FLT3 Signaling