Reactome | Constitutive phosphorylation of FLT3 mutants

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Constitutive phosphorylation of FLT3 mutants Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity	[CatalystActivity:9695837] protein tyrosine kinase activity of FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9695836] Rothfels, Karen, 2020-07-15
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9695834
disease	[Disease:1500689] cancer
displayName	Constitutive phosphorylation of FLT3 mutants
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9703648] Signaling by FLT3 ITD and TKD mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9695841] FLT3 mutant dimers bind GRB2 - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-9695821] FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9683350] Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product [LiteratureReference:9682272] Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies [LiteratureReference:9695676] Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518 [LiteratureReference:9683367] FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells [LiteratureReference:9691008] Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia [LiteratureReference:9696003] Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation [LiteratureReference:9691847] Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML [LiteratureReference:9691860] FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248) [LiteratureReference:9691015] Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML [LiteratureReference:9691838] Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles [LiteratureReference:9691821] Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor [LiteratureReference:9695656] Leukemogenic potency of the novel FLT3-N676K mutant [LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases [LiteratureReference:9683353] Targeting FLT3 mutations in AML: review of current knowledge and evidence [LiteratureReference:9683360] Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: The Path to Least Resistance
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Constitutive phosphorylation of FLT3 mutants
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-9695782] p-6Y FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane]
precedingEvent	[Reaction:R-HSA-9695838] Ligand-independent dimerization of FLT3 mutants - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9695834
summation	[Summation:9696012] Activating mutations in the juxtamembrane, kinase and extrac...

Referrals

(hasEvent)	[Pathway:R-HSA-9703648] Signaling by FLT3 ITD and TKD mutants
(precedingEvent)	[Reaction:R-HSA-9695841] FLT3 mutant dimers bind GRB2

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