Reactome | SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome

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SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome Show undefined attributes

authored	[InstanceEdit:9692648] Shamovsky, Veronica, 2020-06-25
category	binding
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9685275] Shamovsky, Veronica, 2020-04-23
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9685281
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome
edited	[InstanceEdit:9796665] Shamovsky, Veronica, 2022-08-11
eventOf	[Pathway:R-HSA-9692916] SARS-CoV-1 activates/modulates innate immune responses - Homo sapiens
input	[Complex:R-HSA-9685251] NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-COV-9686279] O-glycosyl 3a [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9685267] Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome
output	[Complex:R-HSA-9685242] 3a:NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane]
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713569] D'Eustachio, Peter, 2021-01-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9685281
summation	[Summation:9685262] Severe acute respiratory syndrome coronavirus type 1 (SARS?C...

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[Pathway:R-HSA-9692916] SARS-CoV-1 activates/modulates innate immune responses

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