Reactome | 3CLp cleaves nsp6-11

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3CLp cleaves nsp6-11 Show undefined attributes

authored	[InstanceEdit:9683039] Stephan, Ralf, 2020-04-14
catalystActivity	[CatalystActivity:9684361] cysteine-type endopeptidase activity of 3CLp dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9684359] Stephan, Ralf, 2020-04-21
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9684309
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	3CLp cleaves nsp6-11
edited	[InstanceEdit:9689806] D'Eustachio, Peter, 2020-05-21
eventOf	[Pathway:R-HSA-9684325] Maturation of replicase proteins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9684282] nsp9 forms a homodimer - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-COV-9684354] pp1a-nsp6-11 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9684297] Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	3CLp cleaves nsp6-11
output	[EntityWithAccessionedSequence:R-COV-9678272] pp1a-nsp10 [cytosol] [EntityWithAccessionedSequence:R-COV-9678271] pp1a-nsp11 [cytosol] [EntityWithAccessionedSequence:R-COV-9678265] pp1a-nsp6 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-COV-9678266] pp1a-nsp7 [cytosol] [EntityWithAccessionedSequence:R-COV-9678275] pp1a-nsp8 [cytosol] [EntityWithAccessionedSequence:R-COV-9678273] pp1a-nsp9 [cytosol]
precedingEvent	[Reaction:R-HSA-9684323] 3CLp forms a homodimer - Homo sapiens [Reaction:R-HSA-9684273] 3CLp cleaves pp1a - Homo sapiens
regulatedBy	[NegativeRegulation:9686287] Negative regulation by '3CLp dimer:?-Ketoamides [cytosol]'
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9684309
summation	[Summation:9686301] Main protease cleaves all cleavage sites of pp1a and ppa1b s... [Summation:9684353] Main protease cleaves all cleavage sites of pp1a and ppa1b s...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9684282] nsp9 forms a homodimer
(hasEvent)	[Pathway:R-HSA-9684325] Maturation of replicase proteins

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