Reactome | nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)

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nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) Show undefined attributes

authored	[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30
catalystActivity	[CatalystActivity:9713304] methyltransferase cap1 activity of m7GpppA-capped SARS-CoV-1 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9684031] Orlic-Milacic, Marija, 2020-04-20
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9684030
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)
edited	[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020-05-11
eventOf	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome - Homo sapiens
followingEvent	[Reaction:R-HSA-9685597] RTC binds SARS-CoV-1 genomic RNA complement (minus strand) - Homo sapiens
input	[Complex:R-COV-9713306] m7GpppA-capped SARS-CoV-1 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane] [SimpleEntity:R-ALL-9639461] S-adenosyl-L-methionine [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9683422] In vitro reconstitution of SARS-coronavirus mRNA cap methylation [LiteratureReference:9684045] Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)
output	[EntityWithAccessionedSequence:R-COV-9685513] m7G(5')pppAm-capped SARS-CoV-1 genomic RNA complement (minus strand) [cytosol] [Complex:R-COV-9686016] RTC [double membrane vesicle viral factory outer membrane] [SimpleEntity:R-ALL-9639443] S-adenosyl-L-homocysteine [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9684018] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9684030
summation	[Summation:9685442] The genomic and subgenomic mRNAs of SARS-CoV-1 coronavirus, ...
updateTrackers	[UpdateTracker:9776382] Update Tracker - [Reaction:9684030] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) - v76:[addOutput, add_removeCatalystActivity, add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9776382] Update Tracker - [Reaction:9684030] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) - v76:[addOutput, add_removeCatalystActivity, add_removeInput]
(hasEvent)	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome
(precedingEvent)	[Reaction:R-HSA-9685597] RTC binds SARS-CoV-1 genomic RNA complement (minus strand)

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