Reactome | nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)

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nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) Show undefined attributes

authored	[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30
catalystActivity	[CatalystActivity:9713310] mRNA 5'-cap (guanine-N7-)-methyltransferase activity of SARS-CoV-1 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane]
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9684019] Orlic-Milacic, Marija, 2020-04-20
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9684017
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)
edited	[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020-05-11
eventOf	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome - Homo sapiens
followingEvent	[Reaction:R-HSA-9684032] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand) - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-9639461] S-adenosyl-L-methionine [cytosol] [Complex:R-COV-9713311] SARS-CoV-1 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9684025] Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)
output	[Complex:R-COV-9713313] m7GpppA-capped SARS-CoV-1 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol] [SimpleEntity:R-ALL-9639443] S-adenosyl-L-homocysteine [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9681840] RTC synthesizes SARS-CoV-1 plus strand genomic RNA - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9684017
summation	[Summation:9685170] The genomic and subgenomic mRNAs of SARS-CoV-1 coronavirus, ...
updateTrackers	[UpdateTracker:9776351] Update Tracker - [BlackBoxEvent:9684017] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) - v76:[add_removeCatalystActivity, add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9776351] Update Tracker - [BlackBoxEvent:9684017] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) - v76:[add_removeCatalystActivity, add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome
(precedingEvent)	[Reaction:R-HSA-9684032] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)

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