Reactome | nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template

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nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template Show undefined attributes

authored	[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30
catalystActivity	[CatalystActivity:9713315] 5'-3' RNA helicase activity of SARS coronavirus gRNA with secondary structure:RTC [double membrane vesicle viral factory outer membrane]
category	uncertain
compartment	[Compartment:70101] cytosol [Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9682686] Orlic-Milacic, Marija, 2020-04-13
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9682695
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template
edited	[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020-05-11
eventOf	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9681651] nsp8 generates RNA primers - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-COV-9682668] SARS coronavirus gRNA with secondary structure:RTC [double membrane vesicle viral factory outer membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9682644] Mechanism of nucleic acid unwinding by SARS-CoV helicase [LiteratureReference:9682672] Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13 [LiteratureReference:9682645] Interaction between SARS-CoV helicase and a multifunctional cellular protein (Ddx5) revealed by yeast and mammalian cell two-hybrid systems [LiteratureReference:9682666] Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase [LiteratureReference:9682697] Tertiary structure prediction of SARS coronavirus helicase [LiteratureReference:9682682] The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-COV-9681659] SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane]
precedingEvent	[Reaction:R-HSA-9681314] Replication transcription complex binds SARS-CoV-1 genomic RNA - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9682695
summation	[Summation:9682665] nsp13 is an ATP-dependent human SARS coronavirus 1 (SARS-CoV...
updateTrackers	[UpdateTracker:9776425] Update Tracker - [BlackBoxEvent:9682695] nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template - v76:[add_removeCatalystActivity]

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(updatedInstance)	[UpdateTracker:9776425] Update Tracker - [BlackBoxEvent:9682695] nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template - v76:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome
(precedingEvent)	[BlackBoxEvent:R-HSA-9681651] nsp8 generates RNA primers

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