Reactome | CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane]

Schema > Complex > Entries

CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:9680387] phosphatidylcholine phospholipase C activity of CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] [CatalystActivity:9680386] 1-phosphatidylinositol-3-kinase activity of CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9680377] May, Bruce, 2020-03-27
dbId	9680374
displayName	CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane]
hasComponent	[Complex:R-HSA-389153] CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] [EntityWithAccessionedSequence:R-HSA-200917] FYN [cytosol] [EntityWithAccessionedSequence:R-HSA-202367] GRAP2 [cytosol] [Complex:R-HSA-9680366] GRB2-1:p-Y-GAB3 [cytosol] [Complex:R-HSA-912528] GRB2:p-Y-GAB2 [cytosol] [EntityWithAccessionedSequence:R-HSA-913354] INPPL1 [cytosol] [Complex:R-HSA-9680755] LYN:p-Y-INPP5D [cytosol] [Complex:R-HSA-8876351] p-Y-CBL:GRB2 [cytosol] [EntityWithAccessionedSequence:R-HSA-9029105] p-Y-PLCG2 [cytosol] [EntityWithAccessionedSequence:R-HSA-162568] p-Y-SHC1 [cytosol] [EntityWithAccessionedSequence:R-HSA-9682738] p-Y-THOC5 [cytosol] [DefinedSet:R-HSA-1112571] p-Y701-STAT1, p-Y705-STAT3 [cytosol] [DefinedSet:R-HSA-9680655] PIK3CA,B,D:p-Y-PIK3R1 [cytosol] [EntityWithAccessionedSequence:R-HSA-162563] PTPN11 [cytosol] [EntityWithAccessionedSequence:R-HSA-9628701] SRC [cytosol] [EntityWithAccessionedSequence:R-HSA-373640] YES1 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
isChimeric	false
maxDepth	5
modified	[InstanceEdit:9835202] Rothfels, Karen, 2023-05-12
name	CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2
producedByEvent	[BlackBoxEvent:R-HSA-9680348] PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9680374
updateTrackers	[UpdateTracker:9905220] Update Tracker - [Complex:9680374] CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] - v85:[add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9905220] Update Tracker - [Complex:9680374] CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] - v85:[add_removeHasComponent]
(physicalEntity)	[CatalystActivity:9680387] phosphatidylcholine phospholipase C activity of CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] [CatalystActivity:9680386] 1-phosphatidylinositol-3-kinase activity of CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane]
(output)	[BlackBoxEvent:R-HSA-9680348] PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated

© 2026 Reactome

Cite Us!