Reactome | SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors

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SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors Show undefined attributes

authored	[InstanceEdit:9680260] Jassal, Bijay, 2020-03-26
category	binding
compartment	[Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9680260] Jassal, Bijay, 2020-03-26
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9680262
definition	Inhibition
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors
edited	[InstanceEdit:9680260] Jassal, Bijay, 2020-03-26
eventOf	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome - Homo sapiens
input	[DefinedSet:R-ALL-9687408] RTC inhibitors [double membrane vesicle viral factory outer membrane] [Complex:R-COV-9681663] SARS coronavirus gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9680274] Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase [LiteratureReference:9680275] Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease [LiteratureReference:9680461] The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus [LiteratureReference:9684014] Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses [LiteratureReference:9682443] An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice [LiteratureReference:9682430] Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia [LiteratureReference:9689384] Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors
output	[Complex:R-COV-9680476] SARS coronavirus gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane]
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14 [InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020-05-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9680262
summation	[Summation:9680490] Remdesivir (GS-5734) is an investigational nucleotide analog...
updateTrackers	[UpdateTracker:9775438] Update Tracker - [Reaction:9680262] SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors - v79:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775438] Update Tracker - [Reaction:9680262] SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors - v79:[modifyText]
(hasEvent)	[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome