Reactome | HDAC1:2-containing complex binds HDAC2 Inhibitors

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HDAC1:2-containing complex binds HDAC2 Inhibitors Show undefined attributes

authored	[InstanceEdit:9679866] Jassal, Bijay, 2020-03-25
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9679866] Jassal, Bijay, 2020-03-25
dbId	9679787
definition	Inhibition
displayName	HDAC1:2-containing complex binds HDAC2 Inhibitors
edited	[InstanceEdit:9679866] Jassal, Bijay, 2020-03-25
eventOf	[Pathway:R-HSA-3214815] HDACs deacetylate histones - Homo sapiens [Pathway:R-HSA-9679191] Potential therapeutics for SARS - Homo sapiens
input	[DefinedSet:R-HSA-4657020] HDAC1:2-containing complex [nucleoplasm] [DefinedSet:R-ALL-9679795] HDAC2 inhibitors [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3215320] Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells [LiteratureReference:9685427] Belinostat in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma: Results of the Pivotal Phase II BELIEF (CLN-19) Study [LiteratureReference:9685423] Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma [LiteratureReference:9685437] FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity [LiteratureReference:3215327] Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug [LiteratureReference:9732579] Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	HDAC1:2-containing complex binds HDAC2 Inhibitors
orthologousEvent	[Reaction:R-SCE-9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - Saccharomyces cerevisiae [Reaction:R-SPO-9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - Schizosaccharomyces pombe [Reaction:R-DME-9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - Drosophila melanogaster [Reaction:R-XTR-9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - Xenopus tropicalis [Reaction:R-DRE-9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - Danio rerio [Reaction:R-SSC-9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - Sus scrofa [Reaction:R-BTA-9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - Bos taurus [Reaction:R-CFA-9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - Canis familiaris [Reaction:R-RNO-9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - Rattus norvegicus [Reaction:R-MMU-9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - Mus musculus
output	[Complex:R-HSA-9679831] HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9688552] Shoichet, Brian, 2020-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9679787
summation	[Summation:9685408] To carry out gene expression, a cell must control the windin...
updateTrackers	[UpdateTracker:9776719] Update Tracker - [Reaction:9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - v74:[add_removeInput, modifyText] [UpdateTracker:9776053] Update Tracker - [Reaction:9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - v78:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776719] Update Tracker - [Reaction:9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - v74:[add_removeInput, modifyText] [UpdateTracker:9776053] Update Tracker - [Reaction:9679787] HDAC1:2-containing complex binds HDAC2 Inhibitors - v78:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9679191] Potential therapeutics for SARS [Pathway:R-HSA-3214815] HDACs deacetylate histones

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