Reactome | PTGS1 dimer binds PTGS1 Inhibitors

Schema > Reaction > Entries

PTGS1 dimer binds PTGS1 Inhibitors Show undefined attributes

authored	[InstanceEdit:9677451] Jassal, Bijay, 2020-03-05
category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9677451] Jassal, Bijay, 2020-03-05
dbId	9677320
definition	Inhibition
displayName	PTGS1 dimer binds PTGS1 Inhibitors
edited	[InstanceEdit:9677451] Jassal, Bijay, 2020-03-05 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - Homo sapiens
input	[Complex:R-HSA-428986] PTGS1 dimer [endoplasmic reticulum membrane] [DefinedSet:R-ALL-9677343] PTGS1 Inhibitors [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9677655] Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs [LiteratureReference:9677653] Mechanism of action of aspirin-like drugs [LiteratureReference:9677654] Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs [LiteratureReference:9677491] Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PTGS1 dimer binds PTGS1 Inhibitors
orthologousEvent	[Reaction:R-GGA-9677320] PTGS1 dimer binds PTGS1 Inhibitors - Gallus gallus [Reaction:R-XTR-9677320] PTGS1 dimer binds PTGS1 Inhibitors - Xenopus tropicalis [Reaction:R-DRE-9677320] PTGS1 dimer binds PTGS1 Inhibitors - Danio rerio [Reaction:R-SSC-9677320] PTGS1 dimer binds PTGS1 Inhibitors - Sus scrofa [Reaction:R-BTA-9677320] PTGS1 dimer binds PTGS1 Inhibitors - Bos taurus [Reaction:R-CFA-9677320] PTGS1 dimer binds PTGS1 Inhibitors - Canis familiaris [Reaction:R-RNO-9677320] PTGS1 dimer binds PTGS1 Inhibitors - Rattus norvegicus [Reaction:R-MMU-9677320] PTGS1 dimer binds PTGS1 Inhibitors - Mus musculus
output	[Complex:R-HSA-9677354] PTGS1 dimer:PTGS1 Inhibitors [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9754180] APAP translocates from extracellular region to cytosol - Homo sapiens
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9677320
summation	[Summation:9677621] Prostaglandins are involved in physiological functions such ...

Referrals

(hasEvent)

[Pathway:R-HSA-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX)