Reactome | Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1

Schema > Reaction > Entries

Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 Show undefined attributes

authored	[InstanceEdit:9665478] Orlic-Milacic, Marija, 2019-10-31
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9665710] Orlic-Milacic, Marija, 2019-10-31
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9665701
disease	[Disease:1500689] cancer
displayName	Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus	[EntityFunctionalStatus:9665883] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane]
eventOf	[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9665705] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1 - Homo sapiens
input	[Complex:R-HSA-9665910] p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane] [EntityWithAccessionedSequence:R-HSA-74680] SHC1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9665999] Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1
normalReaction	[Reaction:R-HSA-1963578] SHC1 binds phosphorylated ERBB2 heterodimers
output	[Complex:R-HSA-9665887] p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9665709] ERBB2 TMD/JMD heterodimers trans-autophosphorylate - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9666036] Bose, Ron, 2019-10-25 [InstanceEdit:9666034] Krishna, Anagha, 2019-10-25 [InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9665701
summation	[Summation:9665736] Activation of downstream RAS signaling was shown for ERBB2 S...

Referrals

(hasEvent)	[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants
(precedingEvent)	[Reaction:R-HSA-9665705] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1

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