Reactome | Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer

Schema > Reaction > Entries

Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer Show undefined attributes

authored	[InstanceEdit:9648881] May, Bruce, 2019-06-10
category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9648890] May, Bruce, 2019-06-10
dbId	9648880
displayName	Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer
edited	[InstanceEdit:9648881] May, Bruce, 2019-06-10
eventOf	[Pathway:R-HSA-9648895] Response of EIF2AK1 (HRI) to heme deficiency - Homo sapiens
followingEvent	[Reaction:R-HSA-9648883] p-T-EIF2AK1:ferriheme dimer autophosphorylates - Homo sapiens
inferredFrom	[Reaction:R-OCU-9655573] Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer - Oryctolagus cuniculus [Reaction:R-MMU-9655598] Ferriheme dissociates from p-T-Eif2ak1:2xferriheme dimer - Mus musculus
input	[Complex:R-HSA-9648886] p-T-EIF2AK1:2xferriheme dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9655874] Elucidation of molecular mechanism of stability of the heme-regulated eIF2? kinase upon binding of its ligand, hemin in its catalytic kinase domain
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer
output	2 × [SimpleEntity:R-ALL-917795] FeHM [cytosol] [Complex:R-HSA-9648893] p-T-EIF2AK1:ferriheme dimer [cytosol]
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9664254] Chen, Jane-Jane, 2019-10-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9648880
summation	[Summation:9650725] One molecule of hemin (ferriheme b chloride) tightly binds t...

Referrals

(hasEvent)	[Pathway:R-HSA-9648895] Response of EIF2AK1 (HRI) to heme deficiency
(precedingEvent)	[Reaction:R-HSA-9648883] p-T-EIF2AK1:ferriheme dimer autophosphorylates
(inferredTo)	[Reaction:R-MMU-9655598] Ferriheme dissociates from p-T-Eif2ak1:2xferriheme dimer [Reaction:R-OCU-9655573] Ferriheme dissociates from p-T-EIF2AK1:2xferriheme dimer

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