Reactome | RCE1 cleaves S-Farn proRAS proteins

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RCE1 cleaves S-Farn proRAS proteins Show undefined attributes

authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
catalystActivity	[CatalystActivity:9648000] cysteine-type endopeptidase activity of PolyUb-RCE1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9647998] Rothfels, Karen, 2019-06-04
dbId	9647999
displayName	RCE1 cleaves S-Farn proRAS proteins
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
eventOf	[Pathway:R-HSA-9648002] RAS processing - Homo sapiens
followingEvent	[Reaction:R-HSA-9647977] ICMT methylates S-Farn RAS proteins - Homo sapiens
input	[DefinedSet:R-HSA-9647956] S-Farn-proRAS [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9647854] Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides [LiteratureReference:9647837] Cloning and characterization of a mammalian prenyl protein-specific protease [LiteratureReference:9653446] Rce1: mechanism and inhibition [LiteratureReference:9653444] Posttranslational Modifications of RAS Proteins [LiteratureReference:9653437] Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases [LiteratureReference:5696895] USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity [LiteratureReference:9653287] Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation [LiteratureReference:9653356] Hematologic effects of inactivating the Ras processing enzyme Rce1 [LiteratureReference:9653338] Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells [LiteratureReference:9653382] Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of Ras endoprotease [LiteratureReference:9653451] Selective inhibition of ras-transformed cell growth by a novel fatty acid-based chloromethyl ketone designed to target Ras endoprotease
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RCE1 cleaves S-Farn proRAS proteins
orthologousEvent	[Reaction:R-CEL-9647999] RCE1 cleaves S-Farn proRAS proteins - Caenorhabditis elegans [Reaction:R-DME-9647999] RCE1 cleaves S-Farn proRAS proteins - Drosophila melanogaster [Reaction:R-DRE-9647999] RCE1 cleaves S-Farn proRAS proteins - Danio rerio [Reaction:R-SSC-9647999] RCE1 cleaves S-Farn proRAS proteins - Sus scrofa [Reaction:R-BTA-9647999] RCE1 cleaves S-Farn proRAS proteins - Bos taurus [Reaction:R-CFA-9647999] RCE1 cleaves S-Farn proRAS proteins - Canis familiaris [Reaction:R-RNO-9647999] RCE1 cleaves S-Farn proRAS proteins - Rattus norvegicus [Reaction:R-MMU-9647999] RCE1 cleaves S-Farn proRAS proteins - Mus musculus
output	[DefinedSet:R-HSA-9647959] S-Farn-RAS [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9647978] pro-RAS proteins are farnesylated - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9647999
summation	[Summation:9653497] After prenylation, RAS proteins undergo C-terminal endoprote...

Referrals

(hasEvent)	[Pathway:R-HSA-9648002] RAS processing
(precedingEvent)	[Reaction:R-HSA-9647977] ICMT methylates S-Farn RAS proteins

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