Reactome | FNTB inhibitors bind FNTA:FNTB

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FNTB inhibitors bind FNTA:FNTB Show undefined attributes

authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9647988] Rothfels, Karen, 2019-06-04
dbId	9647987
displayName	FNTB inhibitors bind FNTA:FNTB
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
eventOf	[Pathway:R-HSA-9648002] RAS processing - Homo sapiens [Pathway:R-HSA-9679191] Potential therapeutics for SARS - Homo sapiens
input	[Complex:R-HSA-2530496] FNTA:FNTB [cytosol] [DefinedSet:R-ALL-9653479] FNTB inhibitors [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9647882] Therapeutic strategies for targeting ras proteins [LiteratureReference:9653151] (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent [LiteratureReference:9647823] Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro [LiteratureReference:9653307] Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice [LiteratureReference:9653460] The farnesyl transferase inhibitor SCH 66336 induces a G(2) --> M or G(1) pause in sensitive human tumor cell lines [LiteratureReference:9647847] Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view [LiteratureReference:9729276] Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	FNTB inhibitors bind FNTA:FNTB
orthologousEvent	[Reaction:R-RNO-9647987] FNTB inhibitors bind FNTA:FNTB - Rattus norvegicus [Reaction:R-PFA-9647987] FNTB inhibitors bind FNTA:FNTB - Plasmodium falciparum [Reaction:R-SCE-9647987] FNTB inhibitors bind FNTA:FNTB - Saccharomyces cerevisiae [Reaction:R-SPO-9647987] FNTB inhibitors bind FNTA:FNTB - Schizosaccharomyces pombe [Reaction:R-DDI-9647987] FNTB inhibitors bind FNTA:FNTB - Dictyostelium discoideum [Reaction:R-CEL-9647987] FNTB inhibitors bind FNTA:FNTB - Caenorhabditis elegans [Reaction:R-DME-9647987] FNTB inhibitors bind FNTA:FNTB - Drosophila melanogaster [Reaction:R-GGA-9647987] FNTB inhibitors bind FNTA:FNTB - Gallus gallus [Reaction:R-XTR-9647987] FNTB inhibitors bind FNTA:FNTB - Xenopus tropicalis [Reaction:R-DRE-9647987] FNTB inhibitors bind FNTA:FNTB - Danio rerio [Reaction:R-BTA-9647987] FNTB inhibitors bind FNTA:FNTB - Bos taurus [Reaction:R-MMU-9647987] FNTB inhibitors bind FNTA:FNTB - Mus musculus
output	[Complex:R-HSA-9647944] FNTA:FNTB:FTase inhibitors [cytosol]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9647987
summation	[Summation:9653498] Because prenylation is important for RAS membrane localizati...
updateTrackers	[UpdateTracker:9775920] Update Tracker - [Reaction:9647987] FNTB inhibitors bind FNTA:FNTB - v78:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775920] Update Tracker - [Reaction:9647987] FNTB inhibitors bind FNTA:FNTB - v78:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9679191] Potential therapeutics for SARS [Pathway:R-HSA-9648002] RAS processing

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