Reactome | Defective Base Excision Repair Associated with NEIL3

Schema > Pathway > Entries

Defective Base Excision Repair Associated with NEIL3 Show undefined attributes

authored	[InstanceEdit:9634075] Orlic-Milacic, Marija, 2019-01-04
created	[InstanceEdit:9629244] Orlic-Milacic, Marija, 2018-11-19
crossReference	[DatabaseIdentifier:12020777] Mondo:0007179
dbId	9629232
disease	[Disease:9629266] autoimmune hypersensitivity disease
displayName	Defective Base Excision Repair Associated with NEIL3
doi	10.3180/R-HSA-9629232.1
eventOf	[Pathway:R-HSA-9605308] Diseases of Base Excision Repair - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9629245] NEIL3 D132V does not cleave 5-guanidinohydantoin (Gh) - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9629236] Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity [LiteratureReference:9629298] NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture [LiteratureReference:9629302] Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study [LiteratureReference:9629344] Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice [LiteratureReference:9629633] Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress [LiteratureReference:9629631] Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells [LiteratureReference:9629643] The DNA glycosylases OGG1 and NEIL3 influence differentiation potential, proliferation, and senescence-associated signs in neural stem cells [LiteratureReference:9629651] Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia [LiteratureReference:9629932] No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice [LiteratureReference:9629201] NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis [LiteratureReference:9629374] Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context [LiteratureReference:9635978] Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase [LiteratureReference:9635988] The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective Base Excision Repair Associated with NEIL3
normalPathway	[Pathway:R-HSA-73929] Base-Excision Repair, AP Site Formation
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9635970] Zhou, Jia, 2019-02-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9629232
summation	[Summation:9629317] NEIL3 is a DNA N-glycosylase involved in base excision repai...

Referrals

(hasEvent)

[Pathway:R-HSA-9605308] Diseases of Base Excision Repair

Cite Us!