Reactome | ALDH2 transforms GTN to NO

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ALDH2 transforms GTN to NO Show undefined attributes

authored	[InstanceEdit:9724665] Jassal, Bijay, 2021-03-25
category	uncertain
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9620094] Jassal, Bijay, 2018-09-20
dbId	9620103
displayName	ALDH2 transforms GTN to NO
edited	[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-445355] Smooth Muscle Contraction - Homo sapiens
input	[ChemicalDrug:R-ALL-9618878] GTN [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9620111] Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment [LiteratureReference:9620091] Formation of Nitric Oxide by Aldehyde Dehydrogenase-2 Is Necessary and Sufficient for Vascular Bioactivation of Nitroglycerin [LiteratureReference:9620100] Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase [LiteratureReference:9620070] Identification of the enzymatic mechanism of nitroglycerin bioactivation [LiteratureReference:9620045] Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide
maxDepth	1
modified	[InstanceEdit:9929209] D'Eustachio, Peter, 2024-11-22
name	ALDH2 transforms GTN to NO
output	[SimpleEntity:R-ALL-9620115] GDN [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-3697886] NO [mitochondrial matrix]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[Requirement:9929200] Requirement by 'ALDH2 tetramer [mitochondrial matrix]'
regulationReference	[RegulationReference:9929202] Requirement by 'ALDH2 tetramer [mitochondrial matrix]' Formation of Nitric Oxide by Aldehyde Dehydrogenase-2 Is Necessary and Sufficient for Vascular Bioactivation of Nitroglycerin
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01 [InstanceEdit:9929210] Matthews, Lisa, 2024-11-22
revised	[InstanceEdit:9929201] D'Eustachio, Peter, 2024-11-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9620103
summation	[Summation:9620078] In the mid-19th century, nitroglycerin (nitroglycerine, glyc...
updateTrackers	[UpdateTracker:9939754] Update Tracker - [BlackBoxEvent:9620103] ALDH2 transforms GTN to NO - v92:[addCatalystActivity, modifyText, removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9939754] Update Tracker - [BlackBoxEvent:9620103] ALDH2 transforms GTN to NO - v92:[addCatalystActivity, modifyText, removeRegulator]
(hasEvent)	[Pathway:R-HSA-445355] Smooth Muscle Contraction