Reactome | ATP7B transports cytosolic Cu1+ to Golgi lumen

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ATP7B transports cytosolic Cu1+ to Golgi lumen Show undefined attributes

authored	[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
catalystActivity	[CatalystActivity:936774] P-type monovalent copper transporter activity of ATP7B [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
crossReference	[DatabaseIdentifier:12668226] RHEA:10376 [DatabaseIdentifier:9970125] RHEA:25794
dbId	936895
displayName	ATP7B transports cytosolic Cu1+ to Golgi lumen
edited	[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
eventOf	[Pathway:R-HSA-936837] Ion transport by P-type ATPases - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-3299744] Cu1+ [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:936771] The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene [LiteratureReference:936911] Two forms of Wilson disease protein produced by alternative splicing are localized in distinct cellular compartments [LiteratureReference:936807] The Wilson disease gene: spectrum of mutations and their consequences [LiteratureReference:9970131] A primer on copper biology in the brain
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ATP7B transports cytosolic Cu1+ to Golgi lumen Copper sequestration by copper-transporting ATPase 2
orthologousEvent	[Reaction:R-PFA-936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - Plasmodium falciparum [Reaction:R-SCE-936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - Saccharomyces cerevisiae [Reaction:R-SPO-936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - Schizosaccharomyces pombe [Reaction:R-DDI-936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - Dictyostelium discoideum [Reaction:R-CEL-936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - Caenorhabditis elegans [Reaction:R-DME-936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - Drosophila melanogaster [Reaction:R-GGA-936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - Gallus gallus [Reaction:R-XTR-936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - Xenopus tropicalis [Reaction:R-CFA-936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - Canis familiaris [Reaction:R-RNO-936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - Rattus norvegicus [Reaction:R-MMU-936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-9970129] Cu1+ [Golgi lumen] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1014332] He, Lei, 2010-11-15 [InstanceEdit:9971588] D'Eustachio, Peter, 2025-11-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-936895
summation	[Summation:936868] The human gene ATP7B encodes the copper-transporting ATPase ...
updateTrackers	[UpdateTracker:9787897] Update Tracker - [Reaction:936895] ATP7B transports cytosolic Cu2+ to Golgi lumen - v44:[modifyText] [UpdateTracker:9971874] Update Tracker - [Reaction:936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - v95:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9787897] Update Tracker - [Reaction:936895] ATP7B transports cytosolic Cu2+ to Golgi lumen - v44:[modifyText] [UpdateTracker:9971874] Update Tracker - [Reaction:936895] ATP7B transports cytosolic Cu1+ to Golgi lumen - v95:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-936837] Ion transport by P-type ATPases

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