Reactome | Biosynthesis of DPAn-3-derived protectins and resolvins

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Biosynthesis of DPAn-3-derived protectins and resolvins Show undefined attributes

authored	[InstanceEdit:9026287] Jassal, Bijay, 2017-10-19
created	[InstanceEdit:9026287] Jassal, Bijay, 2017-10-19
crossReference	[DatabaseIdentifier:12819487] BioModels Database:BIOMD0000000106
dbId	9026286
displayName	Biosynthesis of DPAn-3-derived protectins and resolvins
edited	[InstanceEdit:9026287] Jassal, Bijay, 2017-10-19
eventOf	[Pathway:R-HSA-9025094] Biosynthesis of DPAn-3 SPMs - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:9980] lipoxygenase pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9026003] ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 - Homo sapiens [Reaction:R-HSA-9025999] ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 - Homo sapiens [Reaction:R-HSA-9026000] Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA - Homo sapiens [Reaction:R-HSA-9025996] ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 - Homo sapiens [Reaction:R-HSA-9026001] Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA - Homo sapiens [Reaction:R-HSA-9025995] ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 - Homo sapiens [Reaction:R-HSA-9026008] Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA - Homo sapiens [BlackBoxEvent:R-HSA-9031896] PD1n-3, PD2n-3 translocate from cytosol to extracellular region - Homo sapiens [BlackBoxEvent:R-HSA-9031881] DPAn-3 resolvins translocate from cytosol to extracellular region - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-06-13
literatureReference	[LiteratureReference:9025105] Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid [LiteratureReference:9025095] Novel n-3 immunoresolvents: structures and actions [LiteratureReference:9024787] The novel lipid mediator PD1n-3 DPA: An overview of the structural elucidation, synthesis, biosynthesis and bioactions
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Biosynthesis of DPAn-3-derived protectins and resolvins
orthologousEvent	[Pathway:R-DDI-9026286] Biosynthesis of DPAn-3-derived protectins and resolvins - Dictyostelium discoideum [Pathway:R-GGA-9026286] Biosynthesis of DPAn-3-derived protectins and resolvins - Gallus gallus [Pathway:R-XTR-9026286] Biosynthesis of DPAn-3-derived protectins and resolvins - Xenopus tropicalis [Pathway:R-DRE-9026286] Biosynthesis of DPAn-3-derived protectins and resolvins - Danio rerio [Pathway:R-SSC-9026286] Biosynthesis of DPAn-3-derived protectins and resolvins - Sus scrofa [Pathway:R-BTA-9026286] Biosynthesis of DPAn-3-derived protectins and resolvins - Bos taurus [Pathway:R-CFA-9026286] Biosynthesis of DPAn-3-derived protectins and resolvins - Canis familiaris [Pathway:R-RNO-9026286] Biosynthesis of DPAn-3-derived protectins and resolvins - Rattus norvegicus [Pathway:R-MMU-9026286] Biosynthesis of DPAn-3-derived protectins and resolvins - Mus musculus
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9026286
summation	[Summation:9026292] The polyunsaturated fatty acid (PUFA) ?-3 cis-7,10,13,16,19-...
updateTrackers	[UpdateTracker:9779336] Update Tracker - [Pathway:9026286] Biosynthesis of DPAn-3-derived protectins and resolvins - v65:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9779336] Update Tracker - [Pathway:9026286] Biosynthesis of DPAn-3-derived protectins and resolvins - v65:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9025094] Biosynthesis of DPAn-3 SPMs

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