Reactome | ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6

Schema > Reaction > Entries

ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 Show undefined attributes

authored	[InstanceEdit:9025150] Jassal, Bijay, 2017-10-13
catalystActivity	[CatalystActivity:9022673] arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9025150] Jassal, Bijay, 2017-10-13
dbId	9025152
displayName	ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6
edited	[InstanceEdit:9025150] Jassal, Bijay, 2017-10-13
eventOf	[Pathway:R-HSA-9025106] Biosynthesis of DPAn-6 SPMs - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9031884] DPAn-6 SPMs translocate from cytosol to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-9025155] DPAn-6 [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9025145] Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6) [LiteratureReference:9025096] Metabolism and biological production of resolvins derived from docosapentaenoic acid (DPAn-6) [LiteratureReference:9025952] Docosahexaenoic acid (DHA) and docosapentaenoic acid (DPAn-6) algal oils reduce inflammatory mediators in human peripheral mononuclear cells in vitro and paw edema in vivo [LiteratureReference:9025951] Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase [LiteratureReference:9026002] Total synthesis of neuroprotectin D1 analogues derived from omega-6 docosapentaenoic acid (DPA) and adrenic acid (AdA) from a common pivotal, late-stage intermediate
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6
orthologousEvent	[Reaction:R-DDI-9025152] ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 - Dictyostelium discoideum [Reaction:R-DRE-9025152] ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 - Danio rerio [Reaction:R-SSC-9025152] ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 - Sus scrofa [Reaction:R-BTA-9025152] ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 - Bos taurus [Reaction:R-CFA-9025152] ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 - Canis familiaris [Reaction:R-RNO-9025152] ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 - Rattus norvegicus [Reaction:R-MMU-9025152] ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 - Mus musculus
output	[DefinedSet:R-ALL-9025151] 17(S)-HDPAn-6, 10(S),17(S)-diHDPAn-6 [cytosol]
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9025152
summation	[Summation:9025153] Of the 5-, 12- and 15-lipoxygenases, 15-lipoxygenase is the ...

Referrals

(hasEvent)	[Pathway:R-HSA-9025106] Biosynthesis of DPAn-6 SPMs
(precedingEvent)	[BlackBoxEvent:R-HSA-9031884] DPAn-6 SPMs translocate from cytosol to extracellular region