Reactome | Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1

Schema > Reaction > Entries

Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1 Show undefined attributes

authored	[InstanceEdit:9024999] Jassal, Bijay, 2017-10-11
catalystActivity	[CatalystActivity:9025026] epoxide hydrolase activity of Epoxide hydrolase [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9024999] Jassal, Bijay, 2017-10-11
dbId	9024973
displayName	Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1
edited	[InstanceEdit:9024999] Jassal, Bijay, 2017-10-11
eventOf	[Pathway:R-HSA-9018682] Biosynthesis of maresins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9031802] Maresins translocate from cytosol to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-9025001] 13(S),14(S)-epoxy-DHA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9024980] The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype [LiteratureReference:9024988] Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions [LiteratureReference:9025004] The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells [LiteratureReference:9024984] Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain [LiteratureReference:9024996] Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1
output	[SimpleEntity:R-ALL-9025000] MaR1 [cytosol]
precedingEvent	[Reaction:R-HSA-9024983] ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9024973
summation	[Summation:9025002] Maresin 1 (MaR1, 7(R),14(S)-dihydroxy-docosahexaenoic acid) ...

Referrals

(hasEvent)	[Pathway:R-HSA-9018682] Biosynthesis of maresins
(precedingEvent)	[BlackBoxEvent:R-HSA-9031802] Maresins translocate from cytosol to extracellular region

Cite Us!