Reactome | AGO2 cleaves passenger strand of duplex siRNA

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AGO2 cleaves passenger strand of duplex siRNA Show undefined attributes

authored	[InstanceEdit:203918] Gopinathrao, G, May, B, 2007-11-18 23:55:40
catalystActivity	[CatalystActivity:2106608] RNA endonuclease activity of AGO2:duplex siRNA [cytosol]
catalystActivityReference	[CatalystActivityReference:9643359] endoribonuclease activity of AGO2:duplex siRNA [cytosol] Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9023908] May, Bruce, 2017-09-29
dbId	9023912
deleted	[Deleted:9023924] Deletion of instance: 203934
displayName	AGO2 cleaves passenger strand of duplex siRNA
edited	[InstanceEdit:426442] May, B, 2009-06-10
eventOf	[Pathway:R-HSA-426486] Small interfering RNA (siRNA) biogenesis - Homo sapiens
input	[Complex:R-HSA-2106605] AGO2:duplex siRNA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:203878] Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes [LiteratureReference:203914] RNA helicase A interacts with RISC in human cells and functions in RISC loading [LiteratureReference:210573] Argonaute2 is the catalytic engine of mammalian RNAi [LiteratureReference:426466] Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection [LiteratureReference:427814] Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells [LiteratureReference:427812] Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells [LiteratureReference:561218] Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells [LiteratureReference:1296406] ATP-dependent human RISC assembly pathways [LiteratureReference:2106617] Dicer is dispensable for asymmetric RISC loading in mammals [LiteratureReference:5600673] Structure of C3PO and mechanism of human RISC activation
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	AGO2 cleaves passenger strand of duplex siRNA
orthologousEvent	[Reaction:R-SSC-9023912] AGO2 cleaves passenger strand of duplex siRNA - Sus scrofa [Reaction:R-SPO-9023912] AGO2 cleaves passenger strand of duplex siRNA - Schizosaccharomyces pombe [Reaction:R-CEL-9023912] AGO2 cleaves passenger strand of duplex siRNA - Caenorhabditis elegans [Reaction:R-DME-9023912] AGO2 cleaves passenger strand of duplex siRNA - Drosophila melanogaster [Reaction:R-GGA-9023912] AGO2 cleaves passenger strand of duplex siRNA - Gallus gallus [Reaction:R-XTR-9023912] AGO2 cleaves passenger strand of duplex siRNA - Xenopus tropicalis [Reaction:R-BTA-9023912] AGO2 cleaves passenger strand of duplex siRNA - Bos taurus [Reaction:R-CFA-9023912] AGO2 cleaves passenger strand of duplex siRNA - Canis familiaris [Reaction:R-RNO-9023912] AGO2 cleaves passenger strand of duplex siRNA - Rattus norvegicus [Reaction:R-MMU-9023912] AGO2 cleaves passenger strand of duplex siRNA - Mus musculus
output	[Complex:R-HSA-9023915] AGO2:cleaved duplex siRNA [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-2106625] Duplex siRNA is loaded into Argonaute - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2106616] Tomari, Y, 2012-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9023912
summation	[Summation:426462] C3PO appears to act as a nuclease that hydrolyzes the passen...

Referrals

(replacementInstances)	[Deleted:9023924] Deletion of instance: 203934
(hasEvent)	[Pathway:R-HSA-426486] Small interfering RNA (siRNA) biogenesis

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