Reactome | Loss of MECP2 binding ability to the NCoR/SMRT complex

Schema > Pathway > Entries

authored	[InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9022536] Orlic-Milacic, Marija, 2017-09-25
crossReference	[DatabaseIdentifier:12020964] Mondo:0010726
dbId	9022537
disease	[Disease:9005548] Rett syndrome
displayName	Loss of MECP2 binding ability to the NCoR/SMRT complex
edited	[InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
eventOf	[Pathway:R-HSA-9005891] Loss of function of MECP2 in Rett syndrome - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9005585] MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9005556] Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor [LiteratureReference:8986952] Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Loss of MECP2 binding ability to the NCoR/SMRT complex
normalPathway	[Pathway:R-HSA-8986944] Transcriptional Regulation by MECP2
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07 [InstanceEdit:9608114] Christodoulou, John, 2018-08-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9022537
summation	[Summation:9024207] Missense mutations in the transcriptional repression domain ...

(hasEvent)

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