Reactome | C1-Inh binds and inactivates C1r, C1s

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C1-Inh binds and inactivates C1r, C1s Show undefined attributes

authored	[InstanceEdit:8851433] Jupe, Steve, 2016-01-06
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9021308] Jupe, Steve, 2017-09-18
dbId	9021306
displayName	C1-Inh binds and inactivates C1r, C1s
edited	[InstanceEdit:8959925] Jupe, Steve, 2017-02-01
eventOf	[Pathway:R-HSA-977606] Regulation of Complement cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-8852481] Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates - Homo sapiens
input	[Complex:R-HSA-8959916] Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8852489] Interaction of 125I-labelled complement subcomponents C-1r and C-1s with protease inhibitors in plasma
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	C1-Inh binds and inactivates C1r, C1s
orthologousEvent	[Reaction:R-GGA-9021306] C1-Inh binds and inactivates C1r, C1s - Gallus gallus [Reaction:R-SSC-9021306] C1-Inh binds and inactivates C1r, C1s - Sus scrofa [Reaction:R-BTA-9021306] C1-Inh binds and inactivates C1r, C1s - Bos taurus [Reaction:R-CFA-9021306] C1-Inh binds and inactivates C1r, C1s - Canis familiaris [Reaction:R-RNO-9021306] C1-Inh binds and inactivates C1r, C1s - Rattus norvegicus [Reaction:R-MMU-9021306] C1-Inh binds and inactivates C1r, C1s - Mus musculus
output	[Complex:R-HSA-8959915] Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 [extracellular region]
precedingEvent	[Reaction:R-HSA-8852266] C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s - Homo sapiens
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959927] Bulla, Roberta, 2017-02-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9021306
summation	[Summation:9021307] The plasma protease C1 inhibitor (C1Inh, SERPING1) forms pro...

Referrals

(hasEvent)	[Pathway:R-HSA-977606] Regulation of Complement cascade
(precedingEvent)	[Reaction:R-HSA-8852481] Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates

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