Reactome | Interleukin-21 signaling

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Interleukin-21 signaling Show undefined attributes

authored	[InstanceEdit:9005903] Jupe, Steve, 2017-05-11
created	[InstanceEdit:9020957] Jupe, Steve, 2017-09-12
crossReference	[DatabaseIdentifier:12819447] BioModels Database:BIOMD0000000504 [DatabaseIdentifier:12819649] BioModels Database:BIOMD0000000968 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	9020958
displayName	Interleukin-21 signaling
doi	10.3180/R-HSA-9020958.1
edited	[InstanceEdit:9027591] Jupe, Steve, 2017-11-03
eventOf	[Pathway:R-HSA-451927] Interleukin-2 family signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2266261] interleukin-21-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-9005980] IL21 binds IL21R:JAK1 - Homo sapiens [BlackBoxEvent:R-HSA-9006844] IL21:IL21R:JAK1 binds IL2RG:JAK3 - Homo sapiens [BlackBoxEvent:R-HSA-9006850] IL21 receptor JAK phosphorylation - Homo sapiens [BlackBoxEvent:R-HSA-9006873] IL21 receptor STAT binding - Homo sapiens [BlackBoxEvent:R-HSA-9006870] IL21 receptor STAT phosphorylation - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9006857] Interleukin-21: a double-edged sword with therapeutic potential
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Interleukin-21 signaling
orthologousEvent	[Pathway:R-GGA-9020958] Interleukin-21 signaling - Gallus gallus [Pathway:R-DRE-9020958] Interleukin-21 signaling - Danio rerio [Pathway:R-SSC-9020958] Interleukin-21 signaling - Sus scrofa [Pathway:R-BTA-9020958] Interleukin-21 signaling - Bos taurus [Pathway:R-CFA-9020958] Interleukin-21 signaling - Canis familiaris [Pathway:R-RNO-9020958] Interleukin-21 signaling - Rattus norvegicus [Pathway:R-MMU-9020958] Interleukin-21 signaling - Mus musculus
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9027645] Meldal, Birgit, 2017-11-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9020958
summation	[Summation:9027646] Interleukin-21 (IL21) is a pleiotropic cytokine with four al...

Referrals

(hasEvent)

[Pathway:R-HSA-451927] Interleukin-2 family signaling