Reactome | Factor Xa inhibitors binds Xa

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Factor Xa inhibitors binds Xa Show undefined attributes

authored	[InstanceEdit:9015113] Jassal, Bijay, 2017-08-08
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9015113] Jassal, Bijay, 2017-08-08
dbId	9015111
displayName	Factor Xa inhibitors binds Xa
edited	[InstanceEdit:9015113] Jassal, Bijay, 2017-08-08
eventOf	[Pathway:R-HSA-9769739] Regulation of clotting cascade - Homo sapiens
input	[Complex:R-HSA-140649] factor Xa [plasma membrane] [DefinedSet:R-ALL-9038743] Factor Xa inhibitors [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9015065] Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor [LiteratureReference:9038770] Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor [LiteratureReference:9038767] The new factor Xa inhibitor: Apixaban [LiteratureReference:9038773] Edoxaban, a Novel Oral Factor Xa Inhibitor [LiteratureReference:9603677] Efficacy and toxicity of factor Xa inhibitors
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Factor Xa inhibitors binds Xa
orthologousEvent	[Reaction:R-GGA-9015111] Factor Xa inhibitors binds Xa - Gallus gallus [Reaction:R-XTR-9015111] Factor Xa inhibitors binds Xa - Xenopus tropicalis [Reaction:R-DRE-9015111] Factor Xa inhibitors binds Xa - Danio rerio [Reaction:R-SSC-9015111] Factor Xa inhibitors binds Xa - Sus scrofa [Reaction:R-BTA-9015111] Factor Xa inhibitors binds Xa - Bos taurus [Reaction:R-CFA-9015111] Factor Xa inhibitors binds Xa - Canis familiaris [Reaction:R-RNO-9015111] Factor Xa inhibitors binds Xa - Rattus norvegicus [Reaction:R-MMU-9015111] Factor Xa inhibitors binds Xa - Mus musculus
output	[Complex:R-HSA-9015108] factor Xa:Factor Xa inhibitors [plasma membrane]
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9605574] G�mez-Outes, Antonio, 2018-04-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9015111
summation	[Summation:9015112] Factor Xa (aka Factor X heavy chain), a cleavage product of ...

Referrals

(hasEvent)

[Pathway:R-HSA-9769739] Regulation of clotting cascade