Reactome | GSTZ1 dimer dehalogenates DCA

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GSTZ1 dimer dehalogenates DCA Show undefined attributes

authored	[InstanceEdit:9011587] Jassal, Bijay, 2017-07-03
catalystActivity	[CatalystActivity:9011598] glutathione transferase activity of GSTZ1 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9011587] Jassal, Bijay, 2017-07-03
crossReference	[DatabaseIdentifier:9861800] RHEA:16438
dbId	9011595
displayName	GSTZ1 dimer dehalogenates DCA
edited	[InstanceEdit:9011587] Jassal, Bijay, 2017-07-03
eventOf	[Pathway:R-HSA-204174] Regulation of pyruvate dehydrogenase (PDH) complex - Homo sapiens
followingEvent	[Reaction:R-HSA-9863531] GS-MCA spontaneously hydrolyzes - Homo sapiens
input	[ChemicalDrug:R-ALL-9010792] DCA [mitochondrial matrix] [SimpleEntity:R-ALL-1655887] GSH [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[Book:9011604] 9783540418429 Gribble, G Biotransformation, Toxicology and Pharmacogenomics of Dichloroacetate Natural Production of Organohalogen Compounds [LiteratureReference:9011590] Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1 [LiteratureReference:9011580] Pharmacokinetics, metabolism and toxicology of dichloroacetate [LiteratureReference:71167] Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity [LiteratureReference:9855775] Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a) [LiteratureReference:9861652] Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	GSTZ1 dimer dehalogenates DCA
orthologousEvent	[Reaction:R-DRE-9011595] GSTZ1 dimer dehalogenates DCA - Danio rerio [Reaction:R-DDI-9011595] GSTZ1 dimer dehalogenates DCA - Dictyostelium discoideum [Reaction:R-CEL-9011595] GSTZ1 dimer dehalogenates DCA - Caenorhabditis elegans [Reaction:R-DME-9011595] GSTZ1 dimer dehalogenates DCA - Drosophila melanogaster [Reaction:R-GGA-9011595] GSTZ1 dimer dehalogenates DCA - Gallus gallus [Reaction:R-XTR-9011595] GSTZ1 dimer dehalogenates DCA - Xenopus tropicalis [Reaction:R-SSC-9011595] GSTZ1 dimer dehalogenates DCA - Sus scrofa [Reaction:R-BTA-9011595] GSTZ1 dimer dehalogenates DCA - Bos taurus [Reaction:R-CFA-9011595] GSTZ1 dimer dehalogenates DCA - Canis familiaris [Reaction:R-RNO-9011595] GSTZ1 dimer dehalogenates DCA - Rattus norvegicus [Reaction:R-MMU-9011595] GSTZ1 dimer dehalogenates DCA - Mus musculus
output	[SimpleEntity:R-ALL-9861558] Cl- [mitochondrial matrix] [SimpleEntity:R-ALL-9861569] GS-MCA [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9863531] GS-MCA spontaneously hydrolyzes - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[Requirement:R-HSA-9034405] Requirement by 'GSH [mitochondrial matrix]' [NegativeRegulation:R-HSA-9011727] Negative regulation by 'GS-MCA [mitochondrial matrix]'
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9034401] James, Margaret, 2018-01-05 [InstanceEdit:9862191] Hill, David P, 2024-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9011595
summation	[Summation:9011583] In the liver, dimeric glutathione S-transferase zeta 1 (GSTZ...
updateTrackers	[UpdateTracker:9864299] Update Tracker - [Reaction:9011595] GSTZ1 dimer dehalogenates DCA - v88:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9864299] Update Tracker - [Reaction:9011595] GSTZ1 dimer dehalogenates DCA - v88:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator]
(hasEvent)	[Pathway:R-HSA-204174] Regulation of pyruvate dehydrogenase (PDH) complex
(precedingEvent)	[Reaction:R-HSA-9863531] GS-MCA spontaneously hydrolyzes

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